ID D6RB85_HUMAN Unreviewed; 144 AA. AC D6RB85; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 16-JAN-2019, entry version 58. DE SubName: Full=Calnexin {ECO:0000313|Ensembl:ENSP00000424341}; DE Flags: Fragment; GN Name=CANX {ECO:0000313|Ensembl:ENSP00000424341}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424341, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000424341, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000213|PubMed:19608861} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., RA Walther T.C., Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [3] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [4] {ECO:0000313|Ensembl:ENSP00000424341} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [5] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum CC {ECO:0000256|SAAS:SAAS00583789}. CC -!- SIMILARITY: Belongs to the calreticulin family. CC {ECO:0000256|RuleBase:RU362126, ECO:0000256|SAAS:SAAS00583791}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC113426; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC136604; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D6RB85; -. DR jPOST; D6RB85; -. DR MaxQB; D6RB85; -. DR PeptideAtlas; D6RB85; -. DR PRIDE; D6RB85; -. DR Ensembl; ENST00000514383; ENSP00000424341; ENSG00000127022. DR UCSC; uc063koy.1; human. DR EuPathDB; HostDB:ENSG00000127022.14; -. DR HGNC; HGNC:1473; CANX. DR OpenTargets; ENSG00000127022; -. DR eggNOG; KOG0675; Eukaryota. DR eggNOG; ENOG410XP7T; LUCA. DR GeneTree; ENSGT00940000153639; -. DR ChiTaRS; CANX; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000127022; Expressed in 233 organ(s), highest expression level in oviduct epithelium. DR ExpressionAtlas; D6RB85; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro. DR GO; GO:0006457; P:protein folding; IEA:InterPro. DR InterPro; IPR001580; Calret/calnex. DR InterPro; IPR013320; ConA-like_dom_sf. DR PANTHER; PTHR11073; PTHR11073; 1. DR Pfam; PF00262; Calreticulin; 1. DR SUPFAM; SSF49899; SSF49899; 1. PE 1: Evidence at protein level; KW Chaperone {ECO:0000256|RuleBase:RU362126}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU362126}; KW Proteomics identification {ECO:0000213|EPD:D6RB85, KW ECO:0000213|MaxQB:D6RB85, ECO:0000213|PeptideAtlas:D6RB85}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|RuleBase:RU362126}. FT SIGNAL 1 20 {ECO:0000256|RuleBase:RU362126}. FT CHAIN 21 144 {ECO:0000256|RuleBase:RU362126}. FT /FTId=PRO_5005126717. FT NON_TER 144 144 {ECO:0000313|Ensembl:ENSP00000424341}. SQ SEQUENCE 144 AA; 16008 MW; 70FA99DCF346993B CRC64; MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT APPSSPKVTY KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY DGKWEVEEMK ESKLPGDKGL VLMSRAKHHA ISAKLNKPFL FDTK //