ID   D6RB32_HUMAN            Unreviewed;       162 AA.
AC   D6RB32;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   05-DEC-2018, entry version 58.
DE   SubName: Full=Coagulation factor XI {ECO:0000313|Ensembl:ENSP00000424479};
GN   Name=F11 {ECO:0000313|Ensembl:ENSP00000424479};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424479, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424479, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424479}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC110771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RB32; -.
DR   PeptideAtlas; D6RB32; -.
DR   PRIDE; D6RB32; -.
DR   Ensembl; ENST00000492972; ENSP00000424479; ENSG00000088926.
DR   UCSC; uc003iyz.4; human.
DR   EuPathDB; HostDB:ENSG00000088926.13; -.
DR   HGNC; HGNC:3529; F11.
DR   OpenTargets; ENSG00000088926; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000158569; -.
DR   HOGENOM; HOG000213704; -.
DR   ChiTaRS; F11; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000088926; Expressed in 97 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; D6RB32; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0007596; P:blood coagulation; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd01100; APPLE_Factor_XI_like; 2.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR035696; Coagulation_factor_XI.
DR   InterPro; IPR003609; Pan_app.
DR   PANTHER; PTHR44459:SF1; PTHR44459:SF1; 1.
DR   Pfam; PF00024; PAN_1; 2.
DR   PRINTS; PR00005; APPLEDOMAIN.
DR   SMART; SM00223; APPLE; 2.
DR   PROSITE; PS50948; PAN; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RB32,
KW   ECO:0000213|PeptideAtlas:D6RB32};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    162       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087315.
FT   DOMAIN       20    103       Apple. {ECO:0000259|PROSITE:PS50948}.
FT   DOMAIN      110    162       Apple. {ECO:0000259|PROSITE:PS50948}.
SQ   SEQUENCE   162 AA;  18460 MW;  AD6A185F1D07266D CRC64;
     MIFLYQVVHF ILFTSVSGEC VTQLLKDTCF EGGDITTVFT PSAKYCQVVC TYHPRCLLFT
     FTAESPSEDP TRWFTCVLKD SVTETLPRVN RTAAISGYSF KQCSHQISAC NKDIYVDLDM
     KGINYNSSVA KSAQECQERC TDDVHCHFFT YATRQFPSLE HR
//