ID   D6RAZ4_HUMAN            Unreviewed;       179 AA.
AC   D6RAZ4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Calmegin {ECO:0000313|Ensembl:ENSP00000424593};
DE   Flags: Fragment;
GN   Name=CLGN {ECO:0000313|Ensembl:ENSP00000424593};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424593, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424593, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424593}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|SAAS:SAAS00583789}.
CC   -!- SIMILARITY: Belongs to the calreticulin family.
CC       {ECO:0000256|RuleBase:RU362126, ECO:0000256|SAAS:SAAS00583791}.
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DR   EMBL; AC093671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RAZ4; -.
DR   jPOST; D6RAZ4; -.
DR   MaxQB; D6RAZ4; -.
DR   PeptideAtlas; D6RAZ4; -.
DR   PRIDE; D6RAZ4; -.
DR   Ensembl; ENST00000509477; ENSP00000424593; ENSG00000153132.
DR   UCSC; uc062ztq.1; human.
DR   EuPathDB; HostDB:ENSG00000153132.12; -.
DR   HGNC; HGNC:2060; CLGN.
DR   OpenTargets; ENSG00000153132; -.
DR   eggNOG; KOG0675; Eukaryota.
DR   eggNOG; ENOG410XP7T; LUCA.
DR   GeneTree; ENSGT00940000153639; -.
DR   HOGENOM; HOG000207674; -.
DR   ChiTaRS; CLGN; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000153132; Expressed in 148 organ(s), highest expression level in heart right ventricle.
DR   ExpressionAtlas; D6RAZ4; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001580; Calret/calnex.
DR   InterPro; IPR018124; Calret/calnex_CS.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   PANTHER; PTHR11073; PTHR11073; 1.
DR   Pfam; PF00262; Calreticulin; 1.
DR   PRINTS; PR00626; CALRETICULIN.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00803; CALRETICULIN_1; 1.
PE   1: Evidence at protein level;
KW   Chaperone {ECO:0000256|RuleBase:RU362126};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU362126};
KW   Proteomics identification {ECO:0000213|EPD:D6RAZ4,
KW   ECO:0000213|MaxQB:D6RAZ4, ECO:0000213|PeptideAtlas:D6RAZ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362126}.
FT   SIGNAL        1     19       {ECO:0000256|RuleBase:RU362126}.
FT   CHAIN        20    179       {ECO:0000256|RuleBase:RU362126}.
FT                                /FTId=PRO_5005126713.
FT   NON_TER     179    179       {ECO:0000313|Ensembl:ENSP00000424593}.
SQ   SEQUENCE   179 AA;  20508 MW;  5DE2F3C717DC5480 CRC64;
     MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK YKTPQPIGEV
     YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL KENQVPGDRG LVLKSRAKHH
     AISAVLAKPF IFADKPLIVQ YEVNFQDGID CGGAYIKLLA DTDDLILENF YDKTSYIIM
//