ID   D6RAR4_HUMAN            Unreviewed;       662 AA.
AC   D6RAR4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 75.
DE   SubName: Full=Hepatocyte growth factor activator {ECO:0000313|Ensembl:ENSP00000421801};
GN   Name=HGFAC {ECO:0000313|Ensembl:ENSP00000421801};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421801, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421801, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421801}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00748227}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00479}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL590235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001284368.1; NM_001297439.1.
DR   UniGene; Hs.104; -.
DR   ProteinModelPortal; D6RAR4; -.
DR   jPOST; D6RAR4; -.
DR   PeptideAtlas; D6RAR4; -.
DR   PRIDE; D6RAR4; -.
DR   Ensembl; ENST00000511533; ENSP00000421801; ENSG00000109758.
DR   GeneID; 3083; -.
DR   UCSC; uc010icw.4; human.
DR   CTD; 3083; -.
DR   EuPathDB; HostDB:ENSG00000109758.8; -.
DR   HGNC; HGNC:4894; HGFAC.
DR   OpenTargets; ENSG00000109758; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000159778; -.
DR   HOGENOM; HOG000237314; -.
DR   OMA; ACESLTR; -.
DR   OrthoDB; 1314811at2759; -.
DR   PhylomeDB; D6RAR4; -.
DR   GenomeRNAi; 3083; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000109758; Expressed in 75 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; D6RAR4; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00061; FN1; 1.
DR   CDD; cd00062; FN2; 1.
DR   CDD; cd00108; KR; 1.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.10.10.10; -; 1.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR014394; Coagulation_fac_XII/HGFA.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000083; Fibronectin_type1.
DR   InterPro; IPR000562; FN_type2_dom.
DR   InterPro; IPR036943; FN_type2_sf.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR018056; Kringle_CS.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00039; fn1; 1.
DR   Pfam; PF00040; fn2; 1.
DR   Pfam; PF00051; Kringle; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PIRSF; PIRSF001146; Factor_XII_HGFA; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00058; FN1; 1.
DR   SMART; SM00059; FN2; 1.
DR   SMART; SM00130; KR; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   SUPFAM; SSF57440; SSF57440; 2.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01253; FN1_1; 1.
DR   PROSITE; PS51091; FN1_2; 1.
DR   PROSITE; PS00023; FN2_1; 1.
DR   PROSITE; PS51092; FN2_2; 1.
DR   PROSITE; PS00021; KRINGLE_1; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00037407};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00729996};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034,
KW   ECO:0000256|SAAS:SAAS00745848};
KW   Kringle {ECO:0000256|PROSITE-ProRule:PRU00121,
KW   ECO:0000256|SAAS:SAAS00045973};
KW   Protease {ECO:0000256|RuleBase:RU363034,
KW   ECO:0000256|SAAS:SAAS00745848};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RAR4,
KW   ECO:0000213|PeptideAtlas:D6RAR4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00793883};
KW   Secreted {ECO:0000256|SAAS:SAAS00749664};
KW   Serine protease {ECO:0000256|RuleBase:RU363034,
KW   ECO:0000256|SAAS:SAAS00745848}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36    662       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087349.
FT   DOMAIN      103    150       Fibronectin type-II.
FT                                {ECO:0000259|PROSITE:PS51092}.
FT   DOMAIN      160    198       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      200    240       Fibronectin type-I.
FT                                {ECO:0000259|PROSITE:PS51091}.
FT   DOMAIN      241    279       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      285    367       Kringle. {ECO:0000259|PROSITE:PS50070}.
FT   DOMAIN      415    653       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   ACT_SITE    454    454       Charge relay system.
FT                                {ECO:0000256|PIRSR:PIRSR001146-1}.
FT   ACT_SITE    504    504       Charge relay system.
FT                                {ECO:0000256|PIRSR:PIRSR001146-1}.
FT   ACT_SITE    605    605       Charge relay system.
FT                                {ECO:0000256|PIRSR:PIRSR001146-1}.
FT   DISULFID    169    186       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    188    197       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    250    267       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    269    278       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   662 AA;  71483 MW;  F2A3D607370547F6 CRC64;
     MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV
     TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH
     ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD
     PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT
     RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST
     SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE
     YCRLEACDLE TEGRESLTRV QLSPDLLATL PEPASPGRQA CGRRHKKRTF LRPRIIGGSS
     SLPGSHPWLA AIYIGDSFCA GSLVHTCWVV SAAHCFSHSP PRDSVSVVLG QHFFNRTTDV
     TQTFGIEKYI PYTLYSVFNP SDHDLVLIRL KKKGDRCATR SQFVQPICLP EPGSTFPAGH
     KCQIAGWGHL DENVSGYSSS LREALVPLVA DHKCSSPEVY GADISPNMLC AGYFDCKSDA
     CQGDSGGPLA CEKNGVAYLY GIISWGDGCG RLHKPGVYTR VANYVDWIND RIRPPRRLVA
     PS
//