ID   D6RAQ8_HUMAN            Unreviewed;       107 AA.
AC   D6RAQ8;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Calnexin {ECO:0000313|Ensembl:ENSP00000421813};
DE   Flags: Fragment;
GN   Name=CANX {ECO:0000313|Ensembl:ENSP00000421813};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421813, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421813, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000421813}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|SAAS:SAAS00583789}.
CC   -!- SIMILARITY: Belongs to the calreticulin family.
CC       {ECO:0000256|SAAS:SAAS00583791}.
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DR   EMBL; AC113426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC136604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RAQ8; -.
DR   jPOST; D6RAQ8; -.
DR   MaxQB; D6RAQ8; -.
DR   PeptideAtlas; D6RAQ8; -.
DR   PRIDE; D6RAQ8; -.
DR   Ensembl; ENST00000513246; ENSP00000421813; ENSG00000127022.
DR   UCSC; uc063kpe.1; human.
DR   EuPathDB; HostDB:ENSG00000127022.14; -.
DR   HGNC; HGNC:1473; CANX.
DR   OpenTargets; ENSG00000127022; -.
DR   eggNOG; KOG0675; Eukaryota.
DR   eggNOG; ENOG410XP7T; LUCA.
DR   GeneTree; ENSGT00940000153639; -.
DR   ChiTaRS; CANX; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000127022; Expressed in 233 organ(s), highest expression level in oviduct epithelium.
DR   ExpressionAtlas; D6RAQ8; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001580; Calret/calnex.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   PANTHER; PTHR11073; PTHR11073; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RAQ8,
KW   ECO:0000213|MaxQB:D6RAQ8, ECO:0000213|PeptideAtlas:D6RAQ8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    107       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087718.
FT   NON_TER     107    107       {ECO:0000313|Ensembl:ENSP00000421813}.
SQ   SEQUENCE   107 AA;  11859 MW;  3C0D7313097244D4 CRC64;
     MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT APPSSPKVTY
     KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY DGKWEVE
//