ID   D6RAL9_HUMAN            Unreviewed;       129 AA.
AC   D6RAL9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Endoplasmic reticulum aminopeptidase 1 {ECO:0000313|Ensembl:ENSP00000421697};
DE   Flags: Fragment;
GN   Name=ERAP1 {ECO:0000313|Ensembl:ENSP00000421697};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421697, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421697, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421697}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RAL9; -.
DR   jPOST; D6RAL9; -.
DR   MaxQB; D6RAL9; -.
DR   PeptideAtlas; D6RAL9; -.
DR   PRIDE; D6RAL9; -.
DR   Ensembl; ENST00000507154; ENSP00000421697; ENSG00000164307.
DR   UCSC; uc063fqb.1; human.
DR   EuPathDB; HostDB:ENSG00000164307.12; -.
DR   HGNC; HGNC:18173; ERAP1.
DR   OpenTargets; ENSG00000164307; -.
DR   eggNOG; KOG1046; Eukaryota.
DR   eggNOG; COG0308; LUCA.
DR   GeneTree; ENSGT00940000159086; -.
DR   HOGENOM; HOG000106482; -.
DR   ChiTaRS; ERAP1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164307; Expressed in 220 organ(s), highest expression level in intestine.
DR   ExpressionAtlas; D6RAL9; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   InterPro; IPR033520; ERAP1.
DR   InterPro; IPR001930; Peptidase_M1.
DR   PANTHER; PTHR11533; PTHR11533; 1.
DR   PANTHER; PTHR11533:SF156; PTHR11533:SF156; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RAL9,
KW   ECO:0000213|MaxQB:D6RAL9, ECO:0000213|PeptideAtlas:D6RAL9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    129       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087309.
FT   NON_TER     129    129       {ECO:0000313|Ensembl:ENSP00000421697}.
SQ   SEQUENCE   129 AA;  14558 MW;  65BC5BA48EA52556 CRC64;
     MVFLPLKWSL ATMSFLLSSL LALLTVSTPS WCQSTEASPK RSDGTPFPWN KIRLPEYVIP
     VHYDLLIHAN LTTLTFWGTT KVEITASQPT STIILHSHHL QISRATLRKG AGERLSEEPL
     QVLEHPRQE
//