ID   D6RAF4_HUMAN            Unreviewed;       254 AA.
AC   D6RAF4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   05-DEC-2018, entry version 63.
DE   SubName: Full=Semaphorin-5A {ECO:0000313|Ensembl:ENSP00000421961};
DE   Flags: Fragment;
GN   Name=SEMA5A {ECO:0000313|Ensembl:ENSP00000421961};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421961, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421961, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421961}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AC021088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC034214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RAF4; -.
DR   PeptideAtlas; D6RAF4; -.
DR   PRIDE; D6RAF4; -.
DR   Ensembl; ENST00000513968; ENSP00000421961; ENSG00000112902.
DR   UCSC; uc063cgc.1; human.
DR   EuPathDB; HostDB:ENSG00000112902.11; -.
DR   HGNC; HGNC:10736; SEMA5A.
DR   OpenTargets; ENSG00000112902; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XQZC; LUCA.
DR   GeneTree; ENSGT00940000158036; -.
DR   HOGENOM; HOG000232047; -.
DR   ChiTaRS; SEMA5A; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000112902; Expressed in 218 organ(s), highest expression level in metanephric glomerulus.
DR   ExpressionAtlas; D6RAF4; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RAF4,
KW   ECO:0000213|PeptideAtlas:D6RAF4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    254       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087713.
FT   DOMAIN       35    254       Sema. {ECO:0000259|PROSITE:PS51004}.
FT   NON_TER     254    254       {ECO:0000313|Ensembl:ENSP00000421961}.
SQ   SEQUENCE   254 AA;  28620 MW;  FFA31CB1568A6EE1 CRC64;
     MKGTCVIAWL FSSLGLWRLA HPEAQGTTQC QRTEHPVISY KEIGPWLREF RAKNAVDFSQ
     LTFDPGQKEL VVGARNYLFR LQLEDLSLIQ AVEWECDEAT KKACYSKGKS KEECQNYIRV
     LLVGGDRLFT CGTNAFTPVC TNRSLSNLTE IHDQISGMAR CPYSPQHNST ALLTAGGELY
     AATAMDFPGR DPAIYRSLGI LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH
     DCGKTVFSRA ARVC
//