ID   D6RA37_HUMAN            Unreviewed;       289 AA.
AC   D6RA37;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Tumor suppressor candidate 3 {ECO:0000313|Ensembl:ENSP00000423426};
GN   Name=TUSC3 {ECO:0000313|Ensembl:ENSP00000423426};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423426, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423426, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423426}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC100850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RA37; -.
DR   jPOST; D6RA37; -.
DR   MaxQB; D6RA37; -.
DR   PeptideAtlas; D6RA37; -.
DR   PRIDE; D6RA37; -.
DR   Ensembl; ENST00000509380; ENSP00000423426; ENSG00000104723.
DR   UCSC; uc064kll.1; human.
DR   EuPathDB; HostDB:ENSG00000104723.20; -.
DR   HGNC; HGNC:30242; TUSC3.
DR   OpenTargets; ENSG00000104723; -.
DR   eggNOG; KOG2603; Eukaryota.
DR   eggNOG; ENOG410XR1F; LUCA.
DR   GeneTree; ENSGT00390000012030; -.
DR   HOGENOM; HOG000231301; -.
DR   ChiTaRS; TUSC3; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000104723; Expressed in 211 organ(s), highest expression level in chorionic villus.
DR   ExpressionAtlas; D6RA37; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12692; PTHR12692; 1.
DR   Pfam; PF04756; OST3_OST6; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:D6RA37,
KW   ECO:0000213|MaxQB:D6RA37, ECO:0000213|PeptideAtlas:D6RA37};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     41       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        42    289       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087709.
FT   TRANSMEM    198    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    229    248       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   289 AA;  33089 MW;  F1D0B9325F9D870D CRC64;
     MGARGAPSRR RQAGRRLRYL PTGSFPFLLL LLLLCIQLGG GQKKKENLLA EKVEQLMEWS
     SRRSIFRMNG DKFRKFIKAP PRNYSMIVMF TALQPQRQCS VCRQANEEYQ ILANSWRYSS
     AFCNKLFFSM VDYDEGTDVF QQLNMNSAPT FMHFPPKGRP KRADTFDLQR IGFAAEQLAK
     WIADRTDVHI RVFRPPNYSG TIALALLVSL VGGLLYLRRN NLEFIYNKTG WAMVSLCIVF
     AMTSGQMWNH IRGPPYAHKN PHNGQVSYIH GSSQAQFVAE SHIILVLTS
//