ID   D6RA20_HUMAN            Unreviewed;       901 AA.
AC   D6RA20;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 2.
DT   05-DEC-2018, entry version 71.
DE   SubName: Full=Protocadherin alpha-4 {ECO:0000313|Ensembl:ENSP00000423470};
GN   Name=PCDHA4 {ECO:0000313|Ensembl:ENSP00000423470};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423470, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423470, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423470}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00533980}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00533980}.
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DR   EMBL; AC005609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RA20; -.
DR   PeptideAtlas; D6RA20; -.
DR   PRIDE; D6RA20; -.
DR   Ensembl; ENST00000512229; ENSP00000423470; ENSG00000204967.
DR   UCSC; uc003lhh.3; human.
DR   EuPathDB; HostDB:ENSG00000204967.10; -.
DR   HGNC; HGNC:8670; PCDHA4.
DR   OpenTargets; ENSG00000204967; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000163846; -.
DR   HOGENOM; HOG000220892; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000204967; Expressed in 64 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; D6RA20; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR031904; Cadherin_CBD.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF15974; Cadherin_tail; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS00049551};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00441280};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00441280,
KW   ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D6RA20};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    901       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087338.
FT   TRANSMEM    698    718       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    131       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      155    240       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      264    348       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      372    453       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      477    563       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      594    676       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   901 AA;  97241 MW;  6D8E28D67FC33852 CRC64;
     MEFSWGSGQE SRRLLLLLLL LAAWEAGNGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV
     PRLFRVASKG RGGLLEVNLQ NGILFVNSRI DREELCRRSA ECSIHLEVIV DRPLQVFHVD
     VEVRDINDNP PVFPATQKNL SIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFSL
     EKPPDDELVK GLGLILRKSL DREEAPEIFL VLTATDGGKP ELTGTVQLLI TVLDANDNAP
     AFDRTIYKVR LLENVPNGTL VIKLNASDLD EGLNGDIVYS FSNDISPNVK SKFHIDPITG
     QIIVKGYIDF EESKSYEIIV EGIDKGQLPL SGHCRVIVEV EDNNDNVPDL EFKSLSLPIR
     EDAPLGTVIA LISVSDKDMG VNGLVTCSLT SHVPFKLVST FKNYYSLVLD SALDRESVSA
     YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW
     DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVTARDA
     GVPPLGSNVT LQVFVLDEND NAPALLAPRA GGTGGAVSEL VPWSVGVGHV VAKVRAVDAD
     SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDET DAPRHRLLVL VKDHGEPALT
     ATATVLVSLV ESGQAPKASS RALVGAVGPD AALVDVNVYL IIAICAVSSL LVLTLLLYTA
     LRCSALPTEG ACAPGKPTLV CSSAVGSWSY SQQRRPRVCS GEGPPKTDLM AFSPSLPDSR
     DREDQLQTTE ESFAKPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
     SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPEP KKQTQVSFLL RRKGEASQPR
     Q
//