ID D6R9P5_HUMAN Unreviewed; 120 AA. AC D6R9P5; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 05-DEC-2018, entry version 63. DE RecName: Full=Prolactin receptor {ECO:0000256|RuleBase:RU365035}; DE Short=PRL-R {ECO:0000256|RuleBase:RU365035}; DE Flags: Fragment; GN Name=PRLR {ECO:0000256|RuleBase:RU365035, ECO:0000313|EMBL:AJA40022.1, GN ECO:0000313|Ensembl:ENSP00000423493}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423493, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000423493, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000423493} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|EMBL:AJA40022.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25358647; DOI=10.1530/JME-14-0212; RA Schennink A., Trott J.F., Manjarin R., Lemay D.G., Freking B.A., RA Hovey R.C.; RT "Comparative genomics reveals tissue-specific regulation of prolactin RT receptor gene expression."; RL J. Mol. Endocrinol. 54:1-15(2015). CC -!- FUNCTION: This is a receptor for the anterior pituitary hormone CC prolactin. {ECO:0000256|RuleBase:RU365035}. CC -!- SUBUNIT: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and CC this interaction is prolactin-dependent. CC {ECO:0000256|RuleBase:RU365035}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU365035}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU365035}. CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein CC folding and thereby efficient intracellular transport and cell- CC surface receptor binding. {ECO:0000256|RuleBase:RU365035}. CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or CC activation. {ECO:0000256|RuleBase:RU365035}. CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1 CC subfamily. {ECO:0000256|RuleBase:RU365035}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010368; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091851; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF573643; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KJ651925; AJA40022.1; -; mRNA. DR UniGene; Hs.368587; -. DR UniGene; Hs.602914; -. DR PRIDE; D6R9P5; -. DR Ensembl; ENST00000514206; ENSP00000423493; ENSG00000113494. DR UCSC; uc063cxv.1; human. DR EuPathDB; HostDB:ENSG00000113494.16; -. DR HGNC; HGNC:9446; PRLR. DR OpenTargets; ENSG00000113494; -. DR eggNOG; ENOG410IUSW; Eukaryota. DR eggNOG; ENOG410XRJS; LUCA. DR GeneTree; ENSGT00940000154851; -. DR HOGENOM; HOG000059569; -. DR ChiTaRS; PRLR; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000113494; Expressed in 140 organ(s), highest expression level in placenta. DR ExpressionAtlas; D6R9P5; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004925; F:prolactin receptor activity; IEA:InterPro. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR015152; Growth/epo_recpt_lig-bind. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR033230; PRLR. DR PANTHER; PTHR23036:SF86; PTHR23036:SF86; 1. DR Pfam; PF09067; EpoR_lig-bind; 1. DR SUPFAM; SSF49265; SSF49265; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|RuleBase:RU365035}; KW Metal-binding {ECO:0000256|RuleBase:RU365035}; KW Receptor {ECO:0000256|RuleBase:RU365035, ECO:0000313|EMBL:AJA40022.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|RuleBase:RU365035}; KW Zinc {ECO:0000256|RuleBase:RU365035}. FT SIGNAL 1 24 {ECO:0000256|RuleBase:RU365035}. FT CHAIN 25 120 Prolactin receptor. FT {ECO:0000256|RuleBase:RU365035}. FT /FTId=PRO_5014569942. FT DOMAIN 25 120 EpoR_lig-bind. FT {ECO:0000259|Pfam:PF09067}. FT NON_TER 120 120 {ECO:0000313|EMBL:AJA40022.1, FT ECO:0000313|Ensembl:ENSP00000423493}. SQ SEQUENCE 120 AA; 13632 MW; EC6815191BB7CE78 CRC64; MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD //