ID   D6R9E2_HUMAN            Unreviewed;       640 AA.
AC   D6R9E2;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Adhesion G-protein-coupled receptor F2 {ECO:0000313|Ensembl:ENSP00000422934};
GN   Name=ADGRF2 {ECO:0000313|Ensembl:ENSP00000422934};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422934, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422934, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422934}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS01128750}.
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DR   EMBL; AL356421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6R9E2; -.
DR   PRIDE; D6R9E2; -.
DR   Ensembl; ENST00000507065; ENSP00000422934; ENSG00000164393.
DR   UCSC; uc063oyn.1; human.
DR   EuPathDB; HostDB:ENSG00000164393.8; -.
DR   HGNC; HGNC:18991; ADGRF2.
DR   eggNOG; KOG4193; Eukaryota.
DR   eggNOG; ENOG410XSD2; LUCA.
DR   GeneTree; ENSGT00940000162401; -.
DR   HOGENOM; HOG000112762; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000164393; Expressed in 28 organ(s), highest expression level in skin of abdomen.
DR   ExpressionAtlas; D6R9E2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    640       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087489.
FT   TRANSMEM    380    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    415    440       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    460    483       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    536    559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    580    603       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      323    373       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      378    621       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   640 AA;  71344 MW;  269587D1A83D05ED CRC64;
     MTHILLLYYL VFLLPTESCR TLYQAASKSK EKVPARPHGV CDGVCTDYSQ CTQPCPPDTQ
     GNMGFSCRQK TWHKITDTCQ TLNALNIFEE DSRLVQPFED NIKISVYTGK SETITDMLLQ
     KCPTDLSCVI RNIQQSPWIP GNIAVIVQLL HNISTAIWTG VDEAKMQSYS TIANHILNSK
     SISNWTFIPD RNSSYILLHS VNSFARRLFI DKHPVDISDV FIHTMGTTIS GDNIGKNFTF
     SMRINDTSNE VTGRVLISRD ELRKVPSPSQ VISIAFPTIG AILEASLLEN VTVNGLVLSA
     ILPKELKRIS LIFEKISKSE ERRTQCVGWH SVENRWDQQA CKMIQENSQQ AVCKCRPSKL
     FTSFSILMSP HILESLILTY ITYVGLGISI CSLILCLSIE VLVWSQVTKT EITYLRHVCI
     VNIAATLLMA DVWFIVASFL SGPITHHKGC VAATFFVHFF YLSVFFWMLA KALLILYGIM
     IVFHTLPKSV LVASLFSVGY GCPLAIAAIT VAATEPGKGY LRPEICWLNW DMTKALLAFV
     IPALAIVVVN LITVTLVIVK TQRAAIGNSM FQEVRAIVRI SKNIAILTPL LGLTWGFGVA
     TVIDDRSLAF HIIFSLLNAF QVSPDASDQV QSERIHEDVL
//