ID   D6R9D5_HUMAN            Unreviewed;       224 AA.
AC   D6R9D5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Alpha-L-iduronidase {ECO:0000313|Ensembl:ENSP00000422952};
DE   Flags: Fragment;
GN   Name=IDUA {ECO:0000313|Ensembl:ENSP00000422952};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422952, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422952, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422952}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC019103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6R9D5; -.
DR   SMR; D6R9D5; -.
DR   jPOST; D6R9D5; -.
DR   PeptideAtlas; D6R9D5; -.
DR   PRIDE; D6R9D5; -.
DR   Ensembl; ENST00000502910; ENSP00000422952; ENSG00000127415.
DR   UCSC; uc062uhy.1; human.
DR   EuPathDB; HostDB:ENSG00000127415.12; -.
DR   HGNC; HGNC:5391; IDUA.
DR   OpenTargets; ENSG00000127415; -.
DR   GeneTree; ENSGT00390000015494; -.
DR   HOGENOM; HOG000213960; -.
DR   ChiTaRS; IDUA; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000127415; Expressed in 143 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; D6R9D5; baseline and differential.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   InterPro; IPR000514; Glyco_hydro_39.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF01229; Glyco_hydro_39; 1.
DR   PRINTS; PR00745; GLHYDRLASE39.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01027; GLYCOSYL_HYDROL_F39; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6R9D5,
KW   ECO:0000213|PeptideAtlas:D6R9D5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    224       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087695.
FT   NON_TER     224    224       {ECO:0000313|Ensembl:ENSP00000422952}.
SQ   SEQUENCE   224 AA;  25151 MW;  714167B1A3F59714 CRC64;
     MRPLRPRAAL LALLASLLAA PPVAPAEAPH LVHVDAARAL WPLRRFWRST GFWGSTGRGL
     SYNFTHLDGY LDLLRENQLL PGFELMGSAS GHFTDFEDKQ QVFEWKDLVS SLARRYIGRY
     GLAHVSKWNF ETWNEPDHHD FDNVSMTMQG FLNYYDACSE GLRAASPALR LGGPGDSFHT
     PPRSPLSWGL LRHCHDGTNF FTGEAGVRLD YISLHRKGAR SSIS
//