ID   D6R9C5_HUMAN            Unreviewed;       241 AA.
AC   D6R9C5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   12-SEP-2018, entry version 54.
DE   SubName: Full=Osteopontin {ECO:0000313|Ensembl:ENSP00000422973};
DE   Flags: Fragment;
GN   Name=SPP1 {ECO:0000313|Ensembl:ENSP00000422973};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422973, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422973, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:16807684}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16807684; DOI=10.1007/s11102-006-8916-x;
RA   Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.;
RT   "Phosphoproteomic analysis of the human pituitary.";
RL   Pituitary 9:109-120(2006).
RN   [3] {ECO:0000213|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:rs3-RS3(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000422973}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC131944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6R9C5; -.
DR   MaxQB; D6R9C5; -.
DR   PeptideAtlas; D6R9C5; -.
DR   PRIDE; D6R9C5; -.
DR   Ensembl; ENST00000508233; ENSP00000422973; ENSG00000118785.
DR   UCSC; uc062ybx.1; human.
DR   EuPathDB; HostDB:ENSG00000118785.13; -.
DR   HGNC; HGNC:11255; SPP1.
DR   OpenTargets; ENSG00000118785; -.
DR   GeneTree; ENSGT00390000002509; -.
DR   HOGENOM; HOG000059656; -.
DR   ChiTaRS; SPP1; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000118785; Expressed in 216 organ(s), highest expression level in amniotic fluid.
DR   ExpressionAtlas; D6R9C5; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0001503; P:ossification; IEA:InterPro.
DR   InterPro; IPR002038; Osteopontin.
DR   InterPro; IPR019841; Osteopontin_CS.
DR   PANTHER; PTHR10607; PTHR10607; 2.
DR   Pfam; PF00865; Osteopontin; 1.
DR   PRINTS; PR00216; OSTEOPONTIN.
DR   SMART; SM00017; OSTEO; 1.
DR   PROSITE; PS00884; OSTEOPONTIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6R9C5,
KW   ECO:0000213|PeptideAtlas:D6R9C5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    241       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087488.
FT   NON_TER     241    241       {ECO:0000313|Ensembl:ENSP00000422973}.
SQ   SEQUENCE   241 AA;  27110 MW;  5693F86EB2EE421E CRC64;
     MRIAVICFCL LGITCAIPVK QADSGSSEEK QTLPSKSNES HDHMDDMDDE DDDDHVDSQD
     SIDSNDSDDV DDTDDSHQSD ESHHSDESDE LVTDFPTDLP ATEVFTPVVP TVDTYDGRGD
     SVVYGLRSKS KKFRRPDIQY PDATDEDITS HMESEELNGA YKAIPVAQDL NAPSDWDSRG
     KDSYETSQLD DQSAETHSHK QSRLYKRKAN DESNEHSDVI DSQELSKVSR EFHSHEFHSH
     E
//