ID   D6R923_HUMAN            Unreviewed;       125 AA.
AC   D6R923;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=Transmembrane protein 154 {ECO:0000313|Ensembl:ENSP00000422156};
GN   Name=TMEM154 {ECO:0000313|Ensembl:ENSP00000422156};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422156, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422156, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422156}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC023424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011530018.1; XM_011531716.2.
DR   UniGene; Hs.518900; -.
DR   PeptideAtlas; D6R923; -.
DR   Ensembl; ENST00000504064; ENSP00000422156; ENSG00000170006.
DR   GeneID; 201799; -.
DR   UCSC; uc063agz.1; human.
DR   CTD; 201799; -.
DR   EuPathDB; HostDB:ENSG00000170006.11; -.
DR   HGNC; HGNC:26489; TMEM154.
DR   OpenTargets; ENSG00000170006; -.
DR   eggNOG; ENOG410J2D6; Eukaryota.
DR   eggNOG; ENOG410Z5HS; LUCA.
DR   GeneTree; ENSGT00390000016183; -.
DR   HOGENOM; HOG000154611; -.
DR   OrthoDB; 1505523at2759; -.
DR   ChiTaRS; TMEM154; human.
DR   GenomeRNAi; 201799; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000170006; Expressed in 145 organ(s), highest expression level in blood.
DR   ExpressionAtlas; D6R923; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028064; TMEM154.
DR   Pfam; PF15102; TMEM154; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    125       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087294.
FT   TRANSMEM     76    101       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   125 AA;  13781 MW;  909D882EFA3CCC09 CRC64;
     MQAPRAALVF ALVIALVPVG RGNYEELENS GDTTVESERP NKVTIPSTFA AVTIKETLNA
     NINSTNFAPD ENQLEFILMV LIPLILLVLL LLSVVFLATY YKRKRTKQEP SSQGSQSALQ
     TYLLV
//