ID   D3YTC8_HUMAN            Unreviewed;       286 AA.
AC   D3YTC8;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 70.
DE   SubName: Full=Leukocyte-associated immunoglobulin-like receptor 1 {ECO:0000313|Ensembl:ENSP00000391003};
GN   Name=LAIR1 {ECO:0000313|Ensembl:ENSP00000391003};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391003, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000391003, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000391003}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC245884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001275954.2; NM_001289025.2.
DR   UniGene; Hs.572535; -.
DR   ProteinModelPortal; D3YTC8; -.
DR   jPOST; D3YTC8; -.
DR   PeptideAtlas; D3YTC8; -.
DR   PRIDE; D3YTC8; -.
DR   Ensembl; ENST00000434277; ENSP00000391003; ENSG00000167613.
DR   GeneID; 3903; -.
DR   UCSC; uc032idr.2; human.
DR   CTD; 3903; -.
DR   EuPathDB; HostDB:ENSG00000167613.15; -.
DR   HGNC; HGNC:6477; LAIR1.
DR   OpenTargets; ENSG00000167613; -.
DR   eggNOG; ENOG410J37Q; Eukaryota.
DR   eggNOG; ENOG41119RI; LUCA.
DR   GeneTree; ENSGT00940000162693; -.
DR   HOGENOM; HOG000015184; -.
DR   OrthoDB; 1481318at2759; -.
DR   ChiTaRS; LAIR1; human.
DR   GenomeRNAi; 3903; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167613; Expressed in 163 organ(s), highest expression level in blood.
DR   ExpressionAtlas; D3YTC8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:D3YTC8,
KW   ECO:0000213|MaxQB:D3YTC8, ECO:0000213|PeptideAtlas:D3YTC8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    286       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003052449.
FT   TRANSMEM    163    185       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    120       IG. {ECO:0000259|SMART:SM00409}.
SQ   SEQUENCE   286 AA;  31340 MW;  53FCE0F650369F0D CRC64;
     MSPHPTALLG LVLCLAQTIH TQEDLPRPSI SAEPGTVIPL GSHVTFVCRG PVGVQTFRLE
     RDSRSTYNDT EDVSQASPSE SEARFRIDSV REGNAGLYRC IYYKPPKWSE QSDYLELLVK
     ESSGGPDSPD TEPGSSAGPT QRPSDNSHNE HAPASQGLKA EHLYILIGVS VVFLFCLLLL
     VLFCLHRQNQ IKQGPPRSKD EEQKPQQRPD LAVDVLERTA DKATVNGLPE KDRETDTSAL
     AAGSSQEVTY AQLDHWALTQ RTARAVSPQS TKPMAESITY AAVARH
//