ID   D0EV57_HUMAN            Unreviewed;       346 AA.
AC   D0EV57;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 75.
DE   SubName: Full=HLA class I histocompatibility antigen, alpha chain F {ECO:0000313|Ensembl:ENSP00000345828};
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ACX50639.1};
GN   Name=HLA-F {ECO:0000313|EMBL:ACX50639.1,
GN   ECO:0000313|Ensembl:ENSP00000345828};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACX50639.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000345828, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:ACX50639.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=PBMC {ECO:0000313|EMBL:ACX50639.1};
RA   Wallace L.T., Rudersdorf R., Watkins D.I.;
RT   "The MHC class I alleles of Homo sapiens.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000345828}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:AXS63170.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Banno H., Chua N.-H.;
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL669813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX005428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX927250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR753818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GQ891552; ACX50639.1; -; mRNA.
DR   EMBL; MG021786; AXS63170.1; -; Genomic_DNA.
DR   EMBL; MG021787; AXS63171.1; -; Genomic_DNA.
DR   EMBL; MG021788; AXS63172.1; -; Genomic_DNA.
DR   EMBL; MG193556; AXU98652.1; -; Genomic_DNA.
DR   EMBL; MG193563; AXU98659.1; -; Genomic_DNA.
DR   EMBL; MG193567; AXU98663.1; -; Genomic_DNA.
DR   EMBL; MG249976; AXY96384.1; -; Genomic_DNA.
DR   UniGene; Hs.519972; -.
DR   jPOST; D0EV57; -.
DR   MaxQB; D0EV57; -.
DR   Ensembl; ENST00000342322; ENSP00000345828; ENSG00000137403.
DR   Ensembl; ENST00000383626; ENSP00000373121; ENSG00000206509.
DR   Ensembl; ENST00000422711; ENSP00000395853; ENSG00000235220.
DR   Ensembl; ENST00000435058; ENSP00000408540; ENSG00000237508.
DR   Ensembl; ENST00000444891; ENSP00000402853; ENSG00000229698.
DR   Ensembl; ENST00000549422; ENSP00000450119; ENSG00000229698.
DR   Ensembl; ENST00000550932; ENSP00000450300; ENSG00000206509.
DR   Ensembl; ENST00000551780; ENSP00000447401; ENSG00000237508.
DR   Ensembl; ENST00000551832; ENSP00000448260; ENSG00000235220.
DR   Ensembl; ENST00000552082; ENSP00000447228; ENSG00000137403.
DR   UCSC; uc011evc.3; human.
DR   HGNC; HGNC:4963; HLA-F.
DR   eggNOG; ENOG410IUXN; Eukaryota.
DR   eggNOG; ENOG4111K8F; LUCA.
DR   ChiTaRS; HLA-F; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00465899};
KW   Membrane {ECO:0000256|SAAS:SAAS00910515, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:D0EV57,
KW   ECO:0000213|PeptideAtlas:D0EV57};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00910515,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00910515,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    346       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014569676.
FT   TRANSMEM    305    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      206    284       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   346 AA;  39052 MW;  D4782AA4697D57B2 CRC64;
     MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD
     AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN
     GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY
     LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR
     DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ
     PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV
//