ID   C9WSJ4_HUMAN            Unreviewed;       161 AA.
AC   C9WSJ4;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 47.
DE   SubName: Full=Hepatocyte growth factor isoform 6 {ECO:0000313|EMBL:ACX45438.1};
GN   Name=HGF {ECO:0000313|EMBL:ACX45438.1,
GN   ECO:0000313|Ensembl:ENSP00000496217};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACX45438.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000496217, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|EMBL:ACX45438.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19576567; DOI=10.1016/j.ajhg.2009.06.003;
RA   Schultz J.M., Khan S.N., Ahmed Z.M., Riazuddin S., Waryah A.M.,
RA   Chhatre D., Starost M.F., Ploplis B., Buckley S., Velasquez D.,
RA   Kabra M., Lee K., Hassan M.J., Ali G., Ansar M., Ghosh M.,
RA   Wilcox E.R., Ahmad W., Merlino G., Leal S.M., Riazuddin S.,
RA   Friedman T.B., Morell R.J.;
RT   "Noncoding mutations of HGF are associated with nonsyndromic hearing
RT   loss, DFNB39.";
RL   Am. J. Hum. Genet. 85:25-39(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000496217}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   EMBL; AC004960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ830862; ACX45438.1; -; mRNA.
DR   UniGene; Hs.396530; -.
DR   UniGene; Hs.561679; -.
DR   ProteinModelPortal; C9WSJ4; -.
DR   PeptideAtlas; C9WSJ4; -.
DR   Ensembl; ENST00000643024; ENSP00000496217; ENSG00000019991.
DR   HGNC; HGNC:4893; HGF.
DR   OpenTargets; ENSG00000019991; -.
DR   eggNOG; ENOG410IDXR; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000156019; -.
DR   HOGENOM; HOG000112892; -.
DR   ChiTaRS; HGF; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   ExpressionAtlas; C9WSJ4; baseline and differential.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR003609; Pan_app.
DR   Pfam; PF00051; Kringle; 1.
DR   Pfam; PF00024; PAN_1; 1.
DR   SMART; SM00130; KR; 1.
DR   SMART; SM00473; PAN_AP; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
DR   PROSITE; PS50948; PAN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00045912};
KW   Kringle {ECO:0000256|PROSITE-ProRule:PRU00121,
KW   ECO:0000256|SAAS:SAAS00045973};
KW   Proteomics identification {ECO:0000213|EPD:C9WSJ4,
KW   ECO:0000213|MaxQB:C9WSJ4, ECO:0000213|PeptideAtlas:C9WSJ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    161       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003004727.
FT   DOMAIN       37    123       Apple. {ECO:0000259|PROSITE:PS50948}.
FT   DOMAIN      127    161       Kringle. {ECO:0000259|PROSITE:PS50070}.
SQ   SEQUENCE   161 AA;  18560 MW;  772F0A446EC75A03 CRC64;
     MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK
     TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE
     NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH R
//