ID   C9WSJ3_HUMAN            Unreviewed;       184 AA.
AC   C9WSJ3;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 72.
DE   SubName: Full=Hepatocyte growth factor isoform 6 {ECO:0000313|EMBL:ACX45437.1};
GN   Name=HGF {ECO:0000313|EMBL:ACX45437.1,
GN   ECO:0000313|Ensembl:ENSP00000346164};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACX45437.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000346164, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|EMBL:ACX45437.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:ACX45437.1};
RX   PubMed=19576567; DOI=10.1016/j.ajhg.2009.06.003;
RA   Schultz J.M., Khan S.N., Ahmed Z.M., Riazuddin S., Waryah A.M.,
RA   Chhatre D., Starost M.F., Ploplis B., Buckley S., Velasquez D.,
RA   Kabra M., Lee K., Hassan M.J., Ali G., Ansar M., Ghosh M.,
RA   Wilcox E.R., Ahmad W., Merlino G., Leal S.M., Riazuddin S.,
RA   Friedman T.B., Morell R.J.;
RT   "Noncoding mutations of HGF are associated with nonsyndromic hearing
RT   loss, DFNB39.";
RL   Am. J. Hum. Genet. 85:25-39(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000346164}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   EMBL; AC004960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ830861; ACX45437.1; -; mRNA.
DR   UniGene; Hs.396530; -.
DR   UniGene; Hs.561679; -.
DR   SMR; C9WSJ3; -.
DR   MaxQB; C9WSJ3; -.
DR   PRIDE; C9WSJ3; -.
DR   Ensembl; ENST00000354224; ENSP00000346164; ENSG00000019991.
DR   UCSC; uc064ewk.1; human.
DR   EuPathDB; HostDB:ENSG00000019991.15; -.
DR   HGNC; HGNC:4893; HGF.
DR   OpenTargets; ENSG00000019991; -.
DR   eggNOG; ENOG410IDXR; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000156019; -.
DR   ChiTaRS; HGF; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000019991; Expressed in 183 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9WSJ3; baseline and differential.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR003609; Pan_app.
DR   Pfam; PF00051; Kringle; 1.
DR   Pfam; PF00024; PAN_1; 1.
DR   SMART; SM00130; KR; 1.
DR   SMART; SM00473; PAN_AP; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
DR   PROSITE; PS50948; PAN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00045912};
KW   Kringle {ECO:0000256|PROSITE-ProRule:PRU00121,
KW   ECO:0000256|SAAS:SAAS00045973};
KW   Proteomics identification {ECO:0000213|EPD:C9WSJ3,
KW   ECO:0000213|MaxQB:C9WSJ3, ECO:0000213|PeptideAtlas:C9WSJ3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    184       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014569453.
FT   DOMAIN       37    123       Apple. {ECO:0000259|PROSITE:PS50948}.
FT   DOMAIN      127    184       Kringle. {ECO:0000259|PROSITE:PS50070}.
SQ   SEQUENCE   184 AA;  21032 MW;  DBC15C33D6D61A18 CRC64;
     MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK
     TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE
     NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SGGDDCLVES TFYSIPFWGH
     NSAR
//