ID   C9K080_HUMAN            Unreviewed;       623 AA.
AC   C9K080;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 2.
DT   16-JAN-2019, entry version 80.
DE   SubName: Full=Leucine-rich repeats and immunoglobulin-like domains protein 3 {ECO:0000313|Ensembl:ENSP00000413143};
GN   Name=LRIG3 {ECO:0000313|Ensembl:ENSP00000413143};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413143, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413143, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413143}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC078963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016874279.1; XM_017018790.1.
DR   UniGene; Hs.253736; -.
DR   ProteinModelPortal; C9K080; -.
DR   MaxQB; C9K080; -.
DR   PeptideAtlas; C9K080; -.
DR   PRIDE; C9K080; -.
DR   Ensembl; ENST00000433272; ENSP00000413143; ENSG00000139263.
DR   GeneID; 121227; -.
DR   UCSC; uc058qes.1; human.
DR   CTD; 121227; -.
DR   EuPathDB; HostDB:ENSG00000139263.11; -.
DR   HGNC; HGNC:30991; LRIG3.
DR   OpenTargets; ENSG00000139263; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; KOG4194; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000157098; -.
DR   HOGENOM; HOG000205744; -.
DR   OrthoDB; 161719at2759; -.
DR   ChiTaRS; LRIG3; human.
DR   GenomeRNAi; 121227; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139263; Expressed in 164 organ(s), highest expression level in stomach.
DR   ExpressionAtlas; C9K080; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00369; LRR_TYP; 14.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 15.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01010727};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01010457};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
KW   Proteomics identification {ECO:0000213|MaxQB:C9K080,
KW   ECO:0000213|PeptideAtlas:C9K080};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00597472};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    623       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997948.
FT   DOMAIN      499    598       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   623 AA;  69407 MW;  FAE71746C0CEA045 CRC64;
     MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT CRCLGDLLDC
     SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS
     ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT
     SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA
     LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN
     RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS
     LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN
     AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG
     RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL
     LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN
     IPHLTLPFPT FHSTKLRFLV ICI
//