ID   C9JYR4_HUMAN            Unreviewed;       178 AA.
AC   C9JYR4;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 76.
DE   SubName: Full=Probable ribonuclease 11 {ECO:0000313|Ensembl:ENSP00000401398};
DE   Flags: Fragment;
GN   Name=RNASE11 {ECO:0000313|Ensembl:ENSP00000401398};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401398, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000401398, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000401398}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000451839}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000256|SAAS:SAAS00686975}.
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DR   EMBL; AL163195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; C9JYR4; -.
DR   PRIDE; C9JYR4; -.
DR   Ensembl; ENST00000443456; ENSP00000401398; ENSG00000173464.
DR   Ensembl; ENST00000557503; ENSP00000451839; ENSG00000173464.
DR   UCSC; uc058yul.1; human.
DR   EuPathDB; HostDB:ENSG00000173464.14; -.
DR   HGNC; HGNC:19269; RNASE11.
DR   eggNOG; ENOG410IY14; Eukaryota.
DR   eggNOG; ENOG4111CPE; LUCA.
DR   GeneTree; ENSGT00510000049471; -.
DR   HOGENOM; HOG000137920; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000173464; Expressed in 28 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; C9JYR4; baseline.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029743; RNASE11.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF22; PTHR11437:SF22; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    178       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014086889.
FT   DOMAIN       77    175       RNAse_Pc. {ECO:0000259|Pfam:PF00074}.
FT   NON_TER     178    178       {ECO:0000313|Ensembl:ENSP00000401398}.
SQ   SEQUENCE   178 AA;  20158 MW;  82470247C7C83D7E CRC64;
     METFPLLLLS LGLVLAEASE STMKIIKEEF TDEEMQYDMA KSGQEKQTIE ILMNPILLVK
     NTSLSMSKDD MSSTLLTFRS LHYNDPKGNS SGNDKECCND MTVWRKVSEA NGSCKWSNNF
     IRSSTEVMRR VHRAPSCKFV QNPGISCCES LELENTVCQF TTGKQFPRCQ YHSVTSLE
//