ID   C9JYL6_HUMAN            Unreviewed;       181 AA.
AC   C9JYL6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000313|Ensembl:ENSP00000419080};
DE   Flags: Fragment;
GN   Name=RET {ECO:0000313|Ensembl:ENSP00000419080};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419080, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000419080, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419080}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JYL6; -.
DR   SMR; C9JYL6; -.
DR   IntAct; C9JYL6; 1.
DR   jPOST; C9JYL6; -.
DR   PeptideAtlas; C9JYL6; -.
DR   PRIDE; C9JYL6; -.
DR   Ensembl; ENST00000498820; ENSP00000419080; ENSG00000165731.
DR   UCSC; uc057svx.1; human.
DR   EuPathDB; HostDB:ENSG00000165731.17; -.
DR   HGNC; HGNC:9967; RET.
DR   OpenTargets; ENSG00000165731; -.
DR   GeneTree; ENSGT00940000158499; -.
DR   ChiTaRS; RET; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000165731; Expressed in 147 organ(s), highest expression level in dorsal root ganglion.
DR   ExpressionAtlas; C9JYL6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JYL6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    181       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996533.
FT   TRANSMEM    154    177       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER     181    181       {ECO:0000313|Ensembl:ENSP00000419080}.
SQ   SEQUENCE   181 AA;  19360 MW;  330FD0151FE704EB CRC64;
     MAKATSGAAG LRLLLLLLLP LLGKDVAEEA GCPLSCAVSK RRLECEECGG LGSPTGRCEW
     RQGDGKGITR NFSTCSPSTK TCPDGHCDVV ETQDINICPQ DCLRGSIVGG HEPGEPRGIK
     AGYGTCNCFP EEEKCFCEPE DIQDPLCDEL CRTVIAAAVL FSFIVSVLLS AFCIHCYHKF
     A
//