ID   C9JYG8_HUMAN            Unreviewed;       295 AA.
AC   C9JYG8;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Palmitoleoyl-protein carboxylesterase NOTUM {ECO:0000313|Ensembl:ENSP00000407905};
DE   Flags: Fragment;
GN   Name=NOTUM {ECO:0000313|Ensembl:ENSP00000407905};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407905, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000407905, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000407905}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC145207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JYG8; -.
DR   ESTHER; human-NOTUM; Pectinacetylesterase-Notum.
DR   jPOST; C9JYG8; -.
DR   MaxQB; C9JYG8; -.
DR   PeptideAtlas; C9JYG8; -.
DR   PRIDE; C9JYG8; -.
DR   Ensembl; ENST00000425009; ENSP00000407905; ENSG00000185269.
DR   UCSC; uc060lrz.1; human.
DR   EuPathDB; HostDB:ENSG00000185269.11; -.
DR   HGNC; HGNC:27106; NOTUM.
DR   OpenTargets; ENSG00000185269; -.
DR   eggNOG; KOG4287; Eukaryota.
DR   eggNOG; ENOG410XQKD; LUCA.
DR   GeneTree; ENSGT00390000015892; -.
DR   HOGENOM; HOG000113832; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000185269; Expressed in 136 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9JYG8; baseline and differential.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR004963; PAE/NOTUM.
DR   PANTHER; PTHR21562; PTHR21562; 1.
DR   Pfam; PF03283; PAE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JYG8,
KW   ECO:0000213|PeptideAtlas:C9JYG8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    295       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997919.
FT   NON_TER     295    295       {ECO:0000313|Ensembl:ENSP00000407905}.
SQ   SEQUENCE   295 AA;  32733 MW;  ECCBDFD900CA0632 CRC64;
     MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE
     GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW
     LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI
     PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL
     NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGI
//