ID   C9JXX4_HUMAN            Unreviewed;       233 AA.
AC   C9JXX4;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   13-FEB-2019, entry version 60.
DE   SubName: Full=Insulin-like growth factor-binding protein 5 {ECO:0000313|Ensembl:ENSP00000413474};
DE   Flags: Fragment;
GN   Name=IGFBP5 {ECO:0000313|Ensembl:ENSP00000413474};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413474, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413474, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413474}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JXX4; -.
DR   SMR; C9JXX4; -.
DR   jPOST; C9JXX4; -.
DR   PeptideAtlas; C9JXX4; -.
DR   PRIDE; C9JXX4; -.
DR   Ensembl; ENST00000449583; ENSP00000413474; ENSG00000115461.
DR   UCSC; uc061sgh.1; human.
DR   EuPathDB; HostDB:ENSG00000115461.4; -.
DR   HGNC; HGNC:5474; IGFBP5.
DR   OpenTargets; ENSG00000115461; -.
DR   GeneTree; ENSGT00940000155890; -.
DR   HOGENOM; HOG000253012; -.
DR   ChiTaRS; IGFBP5; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115461; Expressed in 247 organ(s), highest expression level in metanephric glomerulus.
DR   ExpressionAtlas; C9JXX4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR012213; IGFBP-5.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR009168; IGFBP1-6.
DR   InterPro; IPR022321; IGFBP_1-6_chordata.
DR   InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR   PANTHER; PTHR11551; PTHR11551; 2.
DR   PANTHER; PTHR11551:SF4; PTHR11551:SF4; 2.
DR   Pfam; PF00219; IGFBP; 1.
DR   PRINTS; PR01976; IGFBPFAMILY.
DR   SMART; SM00121; IB; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00222; IGFBP_N_1; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JXX4,
KW   ECO:0000213|PeptideAtlas:C9JXX4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    233       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997465.
FT   DOMAIN       23    103       IGFBP N-terminal.
FT                                {ECO:0000259|PROSITE:PS51323}.
FT   NON_TER     233    233       {ECO:0000313|Ensembl:ENSP00000413474}.
SQ   SEQUENCE   233 AA;  25480 MW;  EC741BD14C69859E CRC64;
     MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA
     LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIGCAPGGQR
     HICFSLYYSP HPKLPSPGLW PCAPWPTGAD PPAPSPAERD SREHEEPTTS EMAEETYSPK
     IFRPKHTRIS ELKAEAVKKD RRKKLTQSKF VGGAENTAHP RIISAPEMRQ ESE
//