ID C9JXF9_HUMAN Unreviewed; 257 AA. AC C9JXF9; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 13-FEB-2019, entry version 69. DE SubName: Full=Insulin-like growth factor-binding protein 1 {ECO:0000313|Ensembl:ENSP00000413511}; GN Name=IGFBP1 {ECO:0000313|Ensembl:ENSP00000413511}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413511, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000413511, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000413511} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC091524; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JXF9; -. DR SMR; C9JXF9; -. DR MaxQB; C9JXF9; -. DR PeptideAtlas; C9JXF9; -. DR PRIDE; C9JXF9; -. DR Ensembl; ENST00000457280; ENSP00000413511; ENSG00000146678. DR UCSC; uc064dmg.1; human. DR EuPathDB; HostDB:ENSG00000146678.9; -. DR HGNC; HGNC:5469; IGFBP1. DR OpenTargets; ENSG00000146678; -. DR eggNOG; ENOG410IITJ; Eukaryota. DR eggNOG; ENOG4111H9A; LUCA. DR GeneTree; ENSGT00940000157394; -. DR HOGENOM; HOG000253012; -. DR ChiTaRS; IGFBP1; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000146678; Expressed in 89 organ(s), highest expression level in placenta. DR ExpressionAtlas; C9JXF9; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA. DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro. DR CDD; cd00191; TY; 1. DR Gene3D; 4.10.800.10; -; 1. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR000867; IGFBP-like. DR InterPro; IPR022322; IGFBP1. DR InterPro; IPR009168; IGFBP1-6. DR InterPro; IPR022321; IGFBP_1-6_chordata. DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS. DR InterPro; IPR000716; Thyroglobulin_1. DR InterPro; IPR036857; Thyroglobulin_1_sf. DR PANTHER; PTHR11551; PTHR11551; 1. DR Pfam; PF00219; IGFBP; 1. DR Pfam; PF00086; Thyroglobulin_1; 1. DR PRINTS; PR01976; IGFBPFAMILY. DR PRINTS; PR01977; IGFBPFAMILY1. DR SMART; SM00121; IB; 1. DR SMART; SM00211; TY; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR SUPFAM; SSF57610; SSF57610; 1. DR PROSITE; PS00222; IGFBP_N_1; 1. DR PROSITE; PS51323; IGFBP_N_2; 1. DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1. DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00485231}; KW Proteomics identification {ECO:0000213|MaxQB:C9JXF9, KW ECO:0000213|PeptideAtlas:C9JXF9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 257 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002997319. FT DOMAIN 22 107 IGFBP N-terminal. FT {ECO:0000259|PROSITE:PS51323}. FT DOMAIN 173 249 Thyroglobulin type-1. FT {ECO:0000259|PROSITE:PS51162}. SQ SEQUENCE 257 AA; 27671 MW; 377E5A12F366F096 CRC64; MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQTSMD GEAGLCWCVY PWNGKRIPGS PEIRGDPNCQ IYFNVQN //