ID   C9JX45_HUMAN            Unreviewed;       153 AA.
AC   C9JX45;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Prolyl 4-hydroxylase subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000413542};
DE   Flags: Fragment;
GN   Name=P4HA2 {ECO:0000313|Ensembl:ENSP00000413542};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413542, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413542, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413542}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC034220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC063976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JX45; -.
DR   jPOST; C9JX45; -.
DR   MaxQB; C9JX45; -.
DR   PeptideAtlas; C9JX45; -.
DR   PRIDE; C9JX45; -.
DR   Ensembl; ENST00000453286; ENSP00000413542; ENSG00000072682.
DR   UCSC; uc063gts.1; human.
DR   EuPathDB; HostDB:ENSG00000072682.18; -.
DR   HGNC; HGNC:8547; P4HA2.
DR   OpenTargets; ENSG00000072682; -.
DR   eggNOG; KOG1591; Eukaryota.
DR   eggNOG; ENOG410XS5J; LUCA.
DR   GeneTree; ENSGT00940000157695; -.
DR   HOGENOM; HOG000123630; -.
DR   ChiTaRS; P4HA2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000072682; Expressed in 211 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; C9JX45; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR013547; Pro_4_hyd_alph_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF08336; P4Ha_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JX45,
KW   ECO:0000213|MaxQB:C9JX45, ECO:0000213|PeptideAtlas:C9JX45};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    153       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996525.
FT   DOMAIN       26    153       P4Ha_N. {ECO:0000259|Pfam:PF08336}.
FT   NON_TER     153    153       {ECO:0000313|Ensembl:ENSP00000413542}.
SQ   SEQUENCE   153 AA;  17119 MW;  EF45BD8DB52EC905 CRC64;
     MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS
     WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR
     QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRG
//