ID   C9JWU9_HUMAN            Unreviewed;       213 AA.
AC   C9JWU9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Mesoderm-specific transcript homolog protein {ECO:0000313|Ensembl:ENSP00000407222};
DE   Flags: Fragment;
GN   Name=MEST {ECO:0000313|Ensembl:ENSP00000407222};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407222, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000407222, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000407222}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JWU9; -.
DR   SMR; C9JWU9; -.
DR   ESTHER; human-MEST; MEST-like.
DR   jPOST; C9JWU9; -.
DR   PeptideAtlas; C9JWU9; -.
DR   PRIDE; C9JWU9; -.
DR   Ensembl; ENST00000421001; ENSP00000407222; ENSG00000106484.
DR   UCSC; uc064iaq.1; human.
DR   EuPathDB; HostDB:ENSG00000106484.14; -.
DR   HGNC; HGNC:7028; MEST.
DR   OpenTargets; ENSG00000106484; -.
DR   eggNOG; ENOG410INNB; Eukaryota.
DR   eggNOG; ENOG4111G38; LUCA.
DR   GeneTree; ENSGT00510000047602; -.
DR   HOGENOM; HOG000049677; -.
DR   ChiTaRS; MEST; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106484; Expressed in 234 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9JWU9; baseline and differential.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JWU9,
KW   ECO:0000213|MaxQB:C9JWU9, ECO:0000213|PeptideAtlas:C9JWU9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    213       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996522.
FT   DOMAIN       62    153       AB hydrolase-1.
FT                                {ECO:0000259|Pfam:PF00561}.
FT   NON_TER     213    213       {ECO:0000313|Ensembl:ENSP00000407222}.
SQ   SEQUENCE   213 AA;  24362 MW;  648A7D89F2B87727 CRC64;
     MREWWVQVGL LAVPLLAAYL HIPPPQLSPA LHSWKSSGKF FTYKGLRIFY QDSVGVVGSP
     EIVVLLHGFP TSSYDWYKIW EGLTLRFHRV IALDFLGFGF SDKPRPHHYS IFEQASIVEA
     LLRHLGLQNR RINLLSHDYG DIVAQELLYR YKQNRSGRLT IKSLCLSNGG IFPETHRPLL
     LQKLLKDGGV LSPILTRLMN FFVFSRGLTP VFG
//