ID   ADM5_HUMAN              Reviewed;         153 AA.
AC   C9JUS6;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   RecName: Full=Putative adrenomedullin-5-like protein;
DE   Flags: Precursor;
GN   Name=ADM5; Synonyms=C19orf76;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=18434369; DOI=10.1677/JOE-07-0541;
RA   Takei Y., Hashimoto H., Inoue K., Osaki T., Yoshizawa-Kumagaye K.,
RA   Tsunemi M., Watanabe T.X., Ogoshi M., Minamino N., Ueta Y.;
RT   "Central and peripheral cardiovascular actions of adrenomedullin 5, a
RT   novel member of the calcitonin gene-related peptide family, in
RT   mammals.";
RL   J. Endocrinol. 197:391-400(2008).
CC   -!- FUNCTION: Probable non-functional remnant of adrenomedullin-5.
CC       {ECO:0000269|PubMed:18434369}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adrenomedullin family. {ECO:0000305}.
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DR   EMBL; AC011495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471177; EAW52522.1; -; Genomic_DNA.
DR   EMBL; BC032764; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS46146.1; -.
DR   RefSeq; NP_001094810.1; NM_001101340.1.
DR   UniGene; Hs.311193; -.
DR   UniGene; Hs.607562; -.
DR   ProteinModelPortal; C9JUS6; -.
DR   BioMuta; ADM5; -.
DR   PaxDb; C9JUS6; -.
DR   PRIDE; C9JUS6; -.
DR   ProteomicsDB; 11773; -.
DR   DNASU; 199800; -.
DR   Ensembl; ENST00000420022; ENSP00000393631; ENSG00000224420.
DR   GeneID; 199800; -.
DR   KEGG; hsa:199800; -.
DR   UCSC; uc002pph.3; human.
DR   CTD; 199800; -.
DR   EuPathDB; HostDB:ENSG00000224420.3; -.
DR   GeneCards; ADM5; -.
DR   HGNC; HGNC:27293; ADM5.
DR   neXtProt; NX_C9JUS6; -.
DR   OpenTargets; ENSG00000224420; -.
DR   PharmGKB; PA165393101; -.
DR   eggNOG; ENOG410JMZP; Eukaryota.
DR   eggNOG; ENOG41116Z5; LUCA.
DR   GeneTree; ENSGT00730000112484; -.
DR   HOGENOM; HOG000170821; -.
DR   InParanoid; C9JUS6; -.
DR   OMA; AQCPARW; -.
DR   OrthoDB; 1305602at2759; -.
DR   PhylomeDB; C9JUS6; -.
DR   GenomeRNAi; 199800; -.
DR   PRO; PR:C9JUS6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000224420; Expressed in 92 organ(s), highest expression level in cerebellar hemisphere.
DR   Genevisible; C9JUS6; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    153       Putative adrenomedullin-5-like protein.
FT                                /FTId=PRO_0000392551.
FT   DISULFID     39     44       {ECO:0000250}.
SQ   SEQUENCE   153 AA;  16532 MW;  2AC1CFBEB867B30D CRC64;
     MTIHILILLL LLAFSAQGDL DTAARRGQHQ VPQHRGHVCY LGVCRTHRLA EIIYWIRCLH
     QGALGEGQPR APGPLQLWAP PVARGGSPAR FPGFRPAARG LAQCPARWVT SGTARPLLGF
     SLPICMLELL LHISSPLTPA PETVFPSPSP GCD
//