ID   C9JUI2_HUMAN            Unreviewed;       153 AA.
AC   C9JUI2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 64.
DE   RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
DE   Flags: Fragment;
GN   Name=WNT2 {ECO:0000313|Ensembl:ENSP00000419466};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419466, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000419466, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419466}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|RuleBase:RU003500,
CC       ECO:0000256|SAAS:SAAS00681827}.
CC   -!- SIMILARITY: Belongs to the Wnt family.
CC       {ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}.
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DR   EMBL; AC002465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JUI2; -.
DR   PeptideAtlas; C9JUI2; -.
DR   PRIDE; C9JUI2; -.
DR   Ensembl; ENST00000491214; ENSP00000419466; ENSG00000105989.
DR   UCSC; uc064hjt.1; human.
DR   EuPathDB; HostDB:ENSG00000105989.8; -.
DR   HGNC; HGNC:12780; WNT2.
DR   OpenTargets; ENSG00000105989; -.
DR   eggNOG; KOG3913; Eukaryota.
DR   eggNOG; ENOG410XQZ1; LUCA.
DR   GeneTree; ENSGT00940000159231; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000105989; Expressed in 109 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9JUI2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR009140; Wnt2.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01842; WNT2PROTEIN.
DR   SMART; SM00097; WNT1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Developmental protein {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083909};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00083920};
KW   Extracellular matrix {ECO:0000256|SAAS:SAAS00083931};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JUI2,
KW   ECO:0000213|PeptideAtlas:C9JUI2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00083931};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Wnt signaling pathway {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083917}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    153       Protein Wnt. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996600.
FT   NON_TER     153    153       {ECO:0000313|Ensembl:ENSP00000419466}.
SQ   SEQUENCE   153 AA;  17581 MW;  5381C2ADAAAB3C7B CRC64;
     MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS QRQLCHRHPD
     VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSCKAVLE TRVQVPRGER
     LMYSQDMLAG HGRLQENGRL SLEEVQWGHP GGH
//