ID   C9JUH9_HUMAN            Unreviewed;        81 AA.
AC   C9JUH9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 58.
DE   SubName: Full=Metabotropic glutamate receptor 3 {ECO:0000313|Ensembl:ENSP00000407490};
DE   Flags: Fragment;
GN   Name=GRM3 {ECO:0000313|Ensembl:ENSP00000407490};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407490, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000407490, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000407490}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC002081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JUH9; -.
DR   SMR; C9JUH9; -.
DR   PeptideAtlas; C9JUH9; -.
DR   PRIDE; C9JUH9; -.
DR   Ensembl; ENST00000441140; ENSP00000407490; ENSG00000198822.
DR   UCSC; uc064eyd.1; human.
DR   EuPathDB; HostDB:ENSG00000198822.10; -.
DR   HGNC; HGNC:4595; GRM3.
DR   OpenTargets; ENSG00000198822; -.
DR   eggNOG; KOG1056; Eukaryota.
DR   eggNOG; ENOG410XR6W; LUCA.
DR   GeneTree; ENSGT00940000153406; -.
DR   ChiTaRS; GRM3; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000198822; Expressed in 98 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; C9JUH9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR001234; GPCR_3_mtglu_rcpt_3.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01053; MTABOTROPC3R.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00488977};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JUH9};
KW   Receptor {ECO:0000256|SAAS:SAAS00138718};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00488977};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488977}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25     81       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997442.
FT   NON_TER      81     81       {ECO:0000313|Ensembl:ENSP00000407490}.
SQ   SEQUENCE   81 AA;  9149 MW;  126E6A9B6EB4B883 CRC64;
     MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK GTGTEECGRI
     NEDRGIQRLE AMLFAIDEIN K
//