ID   C9JT30_HUMAN            Unreviewed;       390 AA.
AC   C9JT30;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Sialic acid-binding Ig-like lectin 8 {ECO:0000313|Ensembl:ENSP00000389142};
GN   Name=SIGLEC8 {ECO:0000313|Ensembl:ENSP00000389142};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389142, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389142, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000389142}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC020914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.447899; -.
DR   ProteinModelPortal; C9JT30; -.
DR   EPD; C9JT30; -.
DR   jPOST; C9JT30; -.
DR   PeptideAtlas; C9JT30; -.
DR   PRIDE; C9JT30; -.
DR   Ensembl; ENST00000430817; ENSP00000389142; ENSG00000105366.
DR   UCSC; uc010yda.3; human.
DR   EuPathDB; HostDB:ENSG00000105366.15; -.
DR   HGNC; HGNC:10877; SIGLEC8.
DR   OpenTargets; ENSG00000105366; -.
DR   eggNOG; ENOG410IJT6; Eukaryota.
DR   eggNOG; ENOG410YKZU; LUCA.
DR   GeneTree; ENSGT00940000153250; -.
DR   HOGENOM; HOG000236324; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105366; Expressed in 94 organ(s), highest expression level in substantia nigra.
DR   ExpressionAtlas; C9JT30; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JT30,
KW   ECO:0000213|PeptideAtlas:C9JT30};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    390       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996597.
FT   TRANSMEM    252    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      144    235       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   390 AA;  42585 MW;  8F17C33BCDCD0117 CRC64;
     MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD
     PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG
     SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TASTALGNGS SLSVLEGQSL RLVCAVNSNP
     PARLSWTRGS LTLCPSRSSN PGLLELPRVH VRDEGEFTCR AQNAQGSQHI SLSLSLQNEG
     TGTSRPVSQV TLAAVGGAGA TALAFLSFCI IFIIVRSCRK KSARPAAGVG DTGMEDAKAI
     RGSASQGPLT ESWKDGNPLK KPPPAVAPSS GEEGELHYAT LSFHKVKPQD PQGQEATDSE
     YSEIKIHKRE TAETQACLRN HNPSSKEVRG
//