ID   C9JST2_HUMAN            Unreviewed;       399 AA.
AC   C9JST2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 4 {ECO:0000313|Ensembl:ENSP00000401962};
DE   Flags: Fragment;
GN   Name=LILRB4 {ECO:0000313|Ensembl:ENSP00000401962};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401962, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000401962, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000401962}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC243962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC245036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JST2; -.
DR   jPOST; C9JST2; -.
DR   PeptideAtlas; C9JST2; -.
DR   PRIDE; C9JST2; -.
DR   Ensembl; ENST00000434286; ENSP00000401962; ENSG00000186818.
DR   UCSC; uc061csw.1; human.
DR   EuPathDB; HostDB:ENSG00000186818.12; -.
DR   HGNC; HGNC:6608; LILRB4.
DR   OpenTargets; ENSG00000186818; -.
DR   eggNOG; ENOG410IHKK; Eukaryota.
DR   eggNOG; ENOG411142H; LUCA.
DR   GeneTree; ENSGT00940000153160; -.
DR   HOGENOM; HOG000234395; -.
DR   ChiTaRS; LILRB4; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000186818; Expressed in 151 organ(s), highest expression level in layer of synovial tissue.
DR   ExpressionAtlas; C9JST2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JST2,
KW   ECO:0000213|PeptideAtlas:C9JST2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    399       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997433.
FT   TRANSMEM    259    279       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    118       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      124    218       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     399    399       {ECO:0000313|Ensembl:ENSP00000401962}.
SQ   SEQUENCE   399 AA;  44209 MW;  4BDEAD0572A4F59B CRC64;
     MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL
     DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA
     YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF
     PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAGPEDQ
     PLMPTGSVPH SGLRRHWEVL IGVLVVSILL LSLLLFLLLQ HWRQGKHRTL AQRQADFQRP
     PGAAEPEPKD GGLQRRSSPA ADVQGENFCA AVKNTQPEDG VEMDTRQSPH DEDPQAVTYA
     KVKHSRPRRE MASPPSPLSG EFLDTKDRQA EEDRQMDTE
//