ID   C9JRA9_HUMAN            Unreviewed;       160 AA.
AC   C9JRA9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Mesoderm-specific transcript homolog protein {ECO:0000313|Ensembl:ENSP00000409768};
DE   Flags: Fragment;
GN   Name=MEST {ECO:0000313|Ensembl:ENSP00000409768};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409768, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000409768, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000409768}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JRA9; -.
DR   ESTHER; human-MEST; MEST-like.
DR   jPOST; C9JRA9; -.
DR   MaxQB; C9JRA9; -.
DR   PeptideAtlas; C9JRA9; -.
DR   PRIDE; C9JRA9; -.
DR   Ensembl; ENST00000433159; ENSP00000409768; ENSG00000106484.
DR   UCSC; uc064iam.1; human.
DR   EuPathDB; HostDB:ENSG00000106484.14; -.
DR   HGNC; HGNC:7028; MEST.
DR   OpenTargets; ENSG00000106484; -.
DR   eggNOG; ENOG410INNB; Eukaryota.
DR   eggNOG; ENOG4111G38; LUCA.
DR   GeneTree; ENSGT00510000047602; -.
DR   HOGENOM; HOG000049677; -.
DR   ChiTaRS; MEST; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106484; Expressed in 234 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9JRA9; baseline and differential.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JRA9,
KW   ECO:0000213|MaxQB:C9JRA9, ECO:0000213|PeptideAtlas:C9JRA9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    160       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997285.
FT   DOMAIN       62    153       AB hydrolase-1.
FT                                {ECO:0000259|Pfam:PF00561}.
FT   NON_TER     160    160       {ECO:0000313|Ensembl:ENSP00000409768}.
SQ   SEQUENCE   160 AA;  18537 MW;  C42987550621C156 CRC64;
     MREWWVQVGL LAVPLLAAYL HIPPPQLSPA LHSWKSSGKF FTYKGLRIFY QDSVGVVGSP
     EIVVLLHGFP TSSYDWYKIW EGLTLRFHRV IALDFLGFGF SDKPRPHHYS IFEQASIVEA
     LLRHLGLQNR RINLLSHDYG DIVAQELLYR YKQNRSGRLT
//