ID   C9JR52_HUMAN            Unreviewed;       166 AA.
AC   C9JR52;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   12-SEP-2018, entry version 58.
DE   SubName: Full=Pleiotrophin {ECO:0000313|Ensembl:ENSP00000376798};
GN   Name=PTN {ECO:0000313|Ensembl:ENSP00000376798};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376798, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376798, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376798}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC018728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JR52; -.
DR   EPD; C9JR52; -.
DR   PeptideAtlas; C9JR52; -.
DR   PRIDE; C9JR52; -.
DR   Ensembl; ENST00000393083; ENSP00000376798; ENSG00000105894.
DR   UCSC; uc064iiz.1; human.
DR   EuPathDB; HostDB:ENSG00000105894.11; -.
DR   HGNC; HGNC:9630; PTN.
DR   OpenTargets; ENSG00000105894; -.
DR   eggNOG; ENOG410IWNA; Eukaryota.
DR   eggNOG; ENOG4111ZWP; LUCA.
DR   GeneTree; ENSGT00390000007640; -.
DR   HOGENOM; HOG000231473; -.
DR   ChiTaRS; PTN; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000105894; Expressed in 233 organ(s), highest expression level in spinal cord.
DR   ExpressionAtlas; C9JR52; baseline and differential.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   Gene3D; 2.20.60.10; -; 1.
DR   Gene3D; 2.30.90.10; -; 1.
DR   InterPro; IPR000762; Midkine_heparin-bd_GF.
DR   InterPro; IPR020090; PTN/MK_C_dom.
DR   InterPro; IPR038130; PTN/MK_C_dom_sf.
DR   InterPro; IPR020091; PTN/MK_diS_sf.
DR   InterPro; IPR020089; PTN/MK_N_dom.
DR   InterPro; IPR037122; PTN/MK_N_dom_sf.
DR   InterPro; IPR020092; PTN_MK_heparin-bd_GF_CS.
DR   PANTHER; PTHR13850; PTHR13850; 1.
DR   Pfam; PF01091; PTN_MK_C; 1.
DR   Pfam; PF05196; PTN_MK_N; 1.
DR   PRINTS; PR00269; PTNMIDKINE.
DR   ProDom; PD005592; PTN_MK_hepar_bd; 1.
DR   SMART; SM00193; PTN; 1.
DR   SUPFAM; SSF57288; SSF57288; 2.
DR   PROSITE; PS00619; PTN_MK_1; 1.
DR   PROSITE; PS00620; PTN_MK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JR52,
KW   ECO:0000213|PeptideAtlas:C9JR52};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    166       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996586.
FT   DOMAIN       34     95       PTN_MK_N. {ECO:0000259|Pfam:PF05196}.
FT   DOMAIN       96    153       PTN_MK_C. {ECO:0000259|Pfam:PF01091}.
SQ   SEQUENCE   166 AA;  18877 MW;  69829BB03FE02FCA CRC64;
     MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW QWSVCVPTSG
     DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK YQFQAWGECD LNTALKTRTG
     SLKRALHNAE CQKTVTISKP CGKLTKPKPQ EKGKWRHRSG ESLRRW
//