ID   C9JQ36_HUMAN            Unreviewed;       182 AA.
AC   C9JQ36;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|Ensembl:ENSP00000408101};
DE   Flags: Fragment;
GN   Name=IL1R1 {ECO:0000313|Ensembl:ENSP00000408101};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408101, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408101, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000408101}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC007271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JQ36; -.
DR   SMR; C9JQ36; -.
DR   jPOST; C9JQ36; -.
DR   PeptideAtlas; C9JQ36; -.
DR   PRIDE; C9JQ36; -.
DR   Ensembl; ENST00000430171; ENSP00000408101; ENSG00000115594.
DR   UCSC; uc061mlz.1; human.
DR   EuPathDB; HostDB:ENSG00000115594.11; -.
DR   HGNC; HGNC:5993; IL1R1.
DR   OpenTargets; ENSG00000115594; -.
DR   eggNOG; ENOG410IQBC; Eukaryota.
DR   eggNOG; ENOG410Z3W1; LUCA.
DR   GeneTree; ENSGT00940000153278; -.
DR   HOGENOM; HOG000208479; -.
DR   ChiTaRS; IL1R1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115594; Expressed in 228 organ(s), highest expression level in palpebral conjunctiva.
DR   ExpressionAtlas; C9JQ36; baseline and differential.
DR   GO; GO:0004909; F:interleukin-1, type I, activating receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR004076; IL-1_rcpt_I-typ.
DR   InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR   PANTHER; PTHR11890; PTHR11890; 1.
DR   PRINTS; PR01538; INTRLEUKN1R1.
DR   PRINTS; PR01536; INTRLKN1R12F.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JQ36,
KW   ECO:0000213|PeptideAtlas:C9JQ36};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    182       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996584.
FT   DOMAIN       44    110       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     182    182       {ECO:0000313|Ensembl:ENSP00000408101}.
SQ   SEQUENCE   182 AA;  21003 MW;  5CA554E5BCD319DF CRC64;
     MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD
     DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL
     CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR
     LI
//