ID   C9JQ14_HUMAN            Unreviewed;       106 AA.
AC   C9JQ14;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 75.
DE   SubName: Full=Tissue factor pathway inhibitor {ECO:0000313|Ensembl:ENSP00000408170};
DE   Flags: Fragment;
GN   Name=TFPI {ECO:0000313|Ensembl:ENSP00000408170};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408170, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408170, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000408170}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000388159}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC007319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC098485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; C9JQ14; -.
DR   MaxQB; C9JQ14; -.
DR   PeptideAtlas; C9JQ14; -.
DR   PRIDE; C9JQ14; -.
DR   Ensembl; ENST00000421427; ENSP00000408170; ENSG00000003436.
DR   Ensembl; ENST00000437725; ENSP00000388159; ENSG00000003436.
DR   UCSC; uc061qmw.1; human.
DR   EuPathDB; HostDB:ENSG00000003436.14; -.
DR   HGNC; HGNC:11760; TFPI.
DR   OpenTargets; ENSG00000003436; -.
DR   eggNOG; KOG4295; Eukaryota.
DR   eggNOG; ENOG410XQNP; LUCA.
DR   GeneTree; ENSGT00940000160767; -.
DR   HOGENOM; HOG000231818; -.
DR   ChiTaRS; TFPI; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000003436; Expressed in 200 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; C9JQ14; baseline and differential.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   InterPro; IPR029864; TFPI1.
DR   PANTHER; PTHR10083:SF317; PTHR10083:SF317; 1.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JQ14,
KW   ECO:0000213|MaxQB:C9JQ14, ECO:0000213|PeptideAtlas:C9JQ14};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    106       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014086887.
FT   DOMAIN       54    104       BPTI/Kunitz inhibitor.
FT                                {ECO:0000259|PROSITE:PS50279}.
FT   NON_TER     106    106       {ECO:0000313|Ensembl:ENSP00000408170}.
SQ   SEQUENCE   106 AA;  12216 MW;  C94ABD71E05B6455 CRC64;
     MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD
     GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTR
//