ID   C9JNR5_HUMAN            Unreviewed;        92 AA.
AC   C9JNR5;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 71.
DE   SubName: Full=Insulin {ECO:0000313|Ensembl:ENSP00000408400};
DE   Flags: Fragment;
GN   Name=INS {ECO:0000313|Ensembl:ENSP00000408400};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408400, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408400, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000408400}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It
CC       increases cell permeability to monosaccharides, amino acids and
CC       fatty acids. It accelerates glycolysis, the pentose phosphate
CC       cycle, and glycogen synthesis in liver.
CC       {ECO:0000256|SAAS:SAAS00037322}.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000256|SAAS:SAAS00383479}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00086928}.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC       {ECO:0000256|SAAS:SAAS00570953}.
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DR   EMBL; AC132217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JNR5; -.
DR   Allergome; 2121; Hom s Insulin.
DR   jPOST; C9JNR5; -.
DR   PeptideAtlas; C9JNR5; -.
DR   PRIDE; C9JNR5; -.
DR   Ensembl; ENST00000421783; ENSP00000408400; ENSG00000254647.
DR   UCSC; uc057xwk.1; human.
DR   EuPathDB; HostDB:ENSG00000254647.6; -.
DR   HGNC; HGNC:6081; INS.
DR   OpenTargets; ENSG00000254647; -.
DR   eggNOG; ENOG410J0XC; Eukaryota.
DR   eggNOG; ENOG4111VJB; LUCA.
DR   GeneTree; ENSGT00390000015440; -.
DR   OrthoDB; 133009at2759; -.
DR   ChiTaRS; INS; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000254647; Expressed in 72 organ(s), highest expression level in type B pancreatic cell.
DR   ExpressionAtlas; C9JNR5; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:AgBase.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:1903576; P:response to L-arginine; ISS:AgBase.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|SAAS:SAAS00037341};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00086931};
KW   Glucose metabolism {ECO:0000256|SAAS:SAAS00037341};
KW   Hormone {ECO:0000256|SAAS:SAAS00086933};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00460239};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25     92       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997264.
FT   DOMAIN       28     86       IlGF. {ECO:0000259|SMART:SM00078}.
FT   NON_TER      92     92       {ECO:0000313|Ensembl:ENSP00000408400}.
SQ   SEQUENCE   92 AA;  10631 MW;  4E099F7685F10D39 CRC64;
     MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED
     LQAGELLQLD AARRQPHTRR LLHRERWNKA LE
//