ID   C9JN07_HUMAN            Unreviewed;       455 AA.
AC   C9JN07;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=HEPACAM family member 2 {ECO:0000313|Ensembl:ENSP00000389592};
GN   Name=HEPACAM2 {ECO:0000313|Ensembl:ENSP00000389592};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389592, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389592, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000389592}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC000119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC002453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001275739.1; NM_001288810.2.
DR   UniGene; Hs.443169; -.
DR   ProteinModelPortal; C9JN07; -.
DR   EPD; C9JN07; -.
DR   PeptideAtlas; C9JN07; -.
DR   PRIDE; C9JN07; -.
DR   Ensembl; ENST00000440868; ENSP00000389592; ENSG00000188175.
DR   GeneID; 253012; -.
DR   UCSC; uc010lff.5; human.
DR   CTD; 253012; -.
DR   EuPathDB; HostDB:ENSG00000188175.9; -.
DR   HGNC; HGNC:27364; HEPACAM2.
DR   OpenTargets; ENSG00000188175; -.
DR   eggNOG; ENOG410IK28; Eukaryota.
DR   eggNOG; ENOG410Z756; LUCA.
DR   GeneTree; ENSGT00530000063550; -.
DR   HOGENOM; HOG000263412; -.
DR   OrthoDB; 964418at2759; -.
DR   GenomeRNAi; 253012; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000188175; Expressed in 84 organ(s), highest expression level in mucosa of sigmoid colon.
DR   ExpressionAtlas; C9JN07; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:C9JN07,
KW   ECO:0000213|PeptideAtlas:C9JN07};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    455       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996483.
FT   TRANSMEM    340    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      137    221       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      223    319       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   455 AA;  51061 MW;  6B9B383D723971F0 CRC64;
     MWLKVFTTFL SFATGACSGL KVTVPSHTVH GVRGQALYLP VHYGFHTPAS DIQIIWLFER
     PHTMPKYLLG SVNKSVVPDL EYQHKFTMMP PNASLLINPL QFPDEGNYIV KVNIQGNGTL
     SASQKIQVTV DDPVTKPVVQ IHPPSGAVEY VGNMTLTCHV EGGTRLAYQW LKNGRPVHTS
     STYSFSPQNN TLHIAPVTKE DIGNYSCLVR NPVSEMESDI IMPIIYYGPY GLQVNSDKGL
     KVGEVFTVDL GEAILFDCSA DSHPPNTYSW IRRTDNTTYI IKHGPRLEVA SEKVAQKTMD
     YVCCAYNNIT GRQDETHFTV IITSVGLEKL AQKGKSLSPL ASITGISLFL IISMCLLFLW
     KKYQPYKGQK QNTGKLKHFQ AMKMLWMTSE YMNLLLFQMF LVFPGSQAGL FQPLIVYRGK
     ICTVQCMKLF STSLPSSKTI QSELSWAKQY IRVKF
//