ID   C9JMN9_HUMAN            Unreviewed;       163 AA.
AC   C9JMN9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=Protein disulfide-isomerase A4 {ECO:0000313|Ensembl:ENSP00000408628};
DE   Flags: Fragment;
GN   Name=PDIA4 {ECO:0000313|Ensembl:ENSP00000408628};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408628, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408628, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000408628}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC093743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JMN9; -.
DR   EPD; C9JMN9; -.
DR   jPOST; C9JMN9; -.
DR   MaxQB; C9JMN9; -.
DR   PeptideAtlas; C9JMN9; -.
DR   PRIDE; C9JMN9; -.
DR   Ensembl; ENST00000413966; ENSP00000408628; ENSG00000155660.
DR   UCSC; uc064izo.1; human.
DR   EuPathDB; HostDB:ENSG00000155660.10; -.
DR   HGNC; HGNC:30167; PDIA4.
DR   OpenTargets; ENSG00000155660; -.
DR   GeneTree; ENSGT00940000157738; -.
DR   ChiTaRS; PDIA4; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000155660; Expressed in 229 organ(s), highest expression level in oviduct epithelium.
DR   ExpressionAtlas; C9JMN9; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JMN9,
KW   ECO:0000213|MaxQB:C9JMN9, ECO:0000213|PeptideAtlas:C9JMN9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    163       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996573.
FT   DOMAIN       95    163       Thioredoxin.
FT                                {ECO:0000259|PROSITE:PS51352}.
FT   COILED       82    110       {ECO:0000256|SAM:Coils}.
FT   NON_TER     163    163       {ECO:0000313|Ensembl:ENSP00000408628}.
SQ   SEQUENCE   163 AA;  18520 MW;  92D2BF18E19A2285 CRC64;
     MRPRKAFLLL LLLGLVQLLA VAGAEGPDED FRQVQANSRR TRPGSGKGEG EPLERRGEGV
     KKQVRVLWNS KHSFSKCDSS NRENAIEDEE EEEEEDDDEE EDDLEVKEEN GVLVLNDANF
     DNFVADKDTV LLEFYAPWCG HCKQFAPEYE KIANILKDKD PPI
//