ID   C9JMJ0_HUMAN            Unreviewed;       772 AA.
AC   C9JMJ0; C9JM08;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   16-JAN-2019, entry version 77.
DE   SubName: Full=Laminin subunit beta-4 {ECO:0000313|Ensembl:ENSP00000402353};
GN   Name=LAMB4 {ECO:0000313|Ensembl:ENSP00000402353};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000402353, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000402353, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000402353}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR   EMBL; AC005048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001304977.1; NM_001318048.1.
DR   UniGene; Hs.62022; -.
DR   ProteinModelPortal; C9JMJ0; -.
DR   jPOST; C9JMJ0; -.
DR   PeptideAtlas; C9JMJ0; -.
DR   PRIDE; C9JMJ0; -.
DR   Ensembl; ENST00000418464; ENSP00000402353; ENSG00000091128.
DR   GeneID; 22798; -.
DR   UCSC; uc064hat.1; human.
DR   CTD; 22798; -.
DR   EuPathDB; HostDB:ENSG00000091128.12; -.
DR   HGNC; HGNC:6491; LAMB4.
DR   OpenTargets; ENSG00000091128; -.
DR   eggNOG; KOG0994; Eukaryota.
DR   eggNOG; ENOG410XPEG; LUCA.
DR   GeneTree; ENSGT00940000162514; -.
DR   HOGENOM; HOG000203831; -.
DR   OrthoDB; 65841at2759; -.
DR   ChiTaRS; LAMB4; human.
DR   GenomeRNAi; 22798; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000091128; Expressed in 83 organ(s), highest expression level in skin of abdomen.
DR   ExpressionAtlas; C9JMJ0; baseline and differential.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR013015; Laminin_IV_B.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00053; Laminin_EGF; 5.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00180; EGF_Lam; 5.
DR   SMART; SM00136; LamNT; 1.
DR   PROSITE; PS01248; EGF_LAM_1; 2.
DR   PROSITE; PS50027; EGF_LAM_2; 5.
DR   PROSITE; PS51116; LAMININ_IVB; 1.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00966286};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JMJ0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    772       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996572.
FT   DOMAIN       24    264       Laminin N-terminal.
FT                                {ECO:0000259|PROSITE:PS51117}.
FT   DOMAIN      265    331       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      332    394       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      395    454       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      455    505       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      506    552       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      545    772       Laminin IV type B.
FT                                {ECO:0000259|PROSITE:PS51116}.
FT   DISULFID    297    306       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    362    371       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    425    434       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    477    486       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    489    503       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    506    518       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    508    525       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    527    536       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   772 AA;  85104 MW;  168E32DD472CDC7E CRC64;
     MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLMASSTCG LSRAQKYCIL
     SYLEGEQKCF ICDSRFPYDP YDQPNSHTIE NVIVSFEPDR EKKWWQSENG LDHVSIRLDL
     EALFRFSHLI LTFKTFRPAA MLVERSTDYG HNWKVFKYFA KDCATSFPNI TSGQAQGVGD
     IVCDSKYSDI EPSTGGEVVL KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLHTLGDAL
     LGRRQNDSLD KYYYALYEMI VRGSCFCNGH ASECRPMQKM RGDVFSPPGM VHGQCVCQHN
     TDGPNCERCK DFFQDAPWRP AADLQDNACR SCSCNSHSSR CHFDMTTYLA SGGLSGGVCE
     DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD GTISGGICVS HSDPALGSVA
     GQCLCKENVE GAKCDQCKPN HYGLSATDPL GCQPCDCNPL GSLPFLTCDV DTGQCLCLSY
     VTGAHCEECT VGYWGLGNHL HGCSPCDCDI GGAYSNVCSP KNGQCECRPH VTGRSCSEPA
     PGYFFAPLNF YLYEAEEATT LQGLAPLGSE TFGQSPAVHV VLGEPVPGNP VTWTGPGFAR
     VLPGAGLRFA VNNIPFPVDF TIAIHYETQS AADWTVQIVV NPPGGSEHCI PKTLQSKPQS
     FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLQGESHA HSHVLVDSAA VQWHNLGSLQ
     PPPPECKQFS CFSFPSSWDY RHPPPHLANF CIFSRDGVSP HWPGWSQTPD LR
//