ID   C9JMA2_HUMAN            Unreviewed;       204 AA.
AC   C9JMA2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 70.
DE   SubName: Full=Mannan-binding lectin serine protease 1 {ECO:0000313|Ensembl:ENSP00000376267};
DE   Flags: Fragment;
GN   Name=MASP1 {ECO:0000313|Ensembl:ENSP00000376267};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376267, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376267, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376267}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AC007920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JMA2; -.
DR   jPOST; C9JMA2; -.
DR   PeptideAtlas; C9JMA2; -.
DR   PRIDE; C9JMA2; -.
DR   Ensembl; ENST00000392475; ENSP00000376267; ENSG00000127241.
DR   UCSC; uc062rgw.1; human.
DR   EuPathDB; HostDB:ENSG00000127241.16; -.
DR   HGNC; HGNC:6901; MASP1.
DR   OpenTargets; ENSG00000127241; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000153970; -.
DR   HOGENOM; HOG000132924; -.
DR   ChiTaRS; MASP1; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000127241; Expressed in 161 organ(s), highest expression level in ectocervix.
DR   ExpressionAtlas; C9JMA2; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00041; CUB; 1.
DR   Gene3D; 2.60.120.290; -; 1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 1.
DR   SMART; SM00042; CUB; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00033343};
KW   EGF-like domain {ECO:0000256|SAAS:SAAS00484897};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JMA2,
KW   ECO:0000213|PeptideAtlas:C9JMA2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00792548};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    204       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008412944.
FT   DOMAIN       18    145       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   NON_TER     204    204       {ECO:0000313|Ensembl:ENSP00000376267}.
SQ   SEQUENCE   204 AA;  23727 MW;  B26C5EF215DDD287 CRC64;
     MRPTFMSFRW LLLYYALCFS LSKASAHTVE LNNMFGQIQS PGYPDSYPSD SEVTWNITVP
     DGFRIKLYFM HFNLESSYLC EYDYVKVETE DQVLATFCGR ETTDTEQTPG QEVVLSPGSF
     MSITFRSDFS NEERFTGFDA HYMAVDVDEC KEREDEELSC DHYCHNYIGG YYCSCRFGYI
     LHTDNRTCRV ECSDNLFTQR TGVI
//