ID   C9JL63_HUMAN            Unreviewed;       594 AA.
AC   C9JL63;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   05-DEC-2018, entry version 64.
DE   SubName: Full=Metabotropic glutamate receptor 2 {ECO:0000313|Ensembl:ENSP00000408906};
GN   Name=GRM2 {ECO:0000313|Ensembl:ENSP00000408906};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408906, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408906, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000408906}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00547656}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00547656}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000256|SAAS:SAAS00547813}.
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DR   EMBL; AC099050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JL63; -.
DR   SMR; C9JL63; -.
DR   PeptideAtlas; C9JL63; -.
DR   PRIDE; C9JL63; -.
DR   Ensembl; ENST00000442933; ENSP00000408906; ENSG00000164082.
DR   UCSC; uc062kho.1; human.
DR   EuPathDB; HostDB:ENSG00000164082.14; -.
DR   HGNC; HGNC:4594; GRM2.
DR   OpenTargets; ENSG00000164082; -.
DR   eggNOG; KOG1056; Eukaryota.
DR   eggNOG; ENOG410XR6W; LUCA.
DR   GeneTree; ENSGT00940000157812; -.
DR   HOGENOM; HOG000218635; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000164082; Expressed in 156 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; C9JL63; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR   InterPro; IPR001458; GPCR_3_mtglu_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01052; MTABOTROPC2R.
DR   PRINTS; PR00593; MTABOTROPICR.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00500778};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00497975};
KW   Membrane {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAAS:SAAS00500778, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JL63};
KW   Receptor {ECO:0000256|SAAS:SAAS00497975};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00497975};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    594       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002997785.
FT   TRANSMEM    483    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    516    534       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      470    555       G_PROTEIN_RECEP_F3_4.
FT                                {ECO:0000259|PROSITE:PS50259}.
SQ   SEQUENCE   594 AA;  65454 MW;  C5D7A441A37025DA CRC64;
     MGSLLALLAL LLLWGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEDC GPVNEHRGIQ
     RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE QALDFVRASL SRGADGSRHI
     CPDGSYATHG DAPTAITGVI GGSYSDVSIQ VANLLRLFQI PQISYASTSA KLSDKSRYDY
     FARTVPPDFF QAKAMAEILR FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK
     VGRAMSRAAF EGVVRALLQK PSARVAVLFT RSEDARELLA ASQRLNASFT WVASDGWGAL
     ESVVAGSEGA AEGAITIELA SYPISDFASY FQSLDPWNNS RNPWFREFWE QRFRCSFRQR
     DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC PNTTRLCDAM RPVNGRRLYK
     DFVLNVKFDA PFRPADTHNE VRFDRFGDGI GRYNIFTYLR AGSGRYRYQK TRKCPENFNE
     AKFIGFTMYT TCIIWLAFLP IFYVTSSDYR VQTTTMCVSV SLSGSVVLGC LFAPKLHIIL
     FQPQKNVVSH RAPTSRFGSA AARASSSLGQ GSGSQFVPTV CNGREVVDST TSSL
//