ID   C9JKY3_HUMAN            Unreviewed;       199 AA.
AC   C9JKY3;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Epithelial cell adhesion molecule {ECO:0000313|Ensembl:ENSP00000389028};
DE   Flags: Fragment;
GN   Name=EPCAM {ECO:0000313|Ensembl:ENSP00000389028};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389028, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389028, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000389028}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   EMBL; AC079775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JKY3; -.
DR   SMR; C9JKY3; -.
DR   EPD; C9JKY3; -.
DR   jPOST; C9JKY3; -.
DR   MaxQB; C9JKY3; -.
DR   PeptideAtlas; C9JKY3; -.
DR   PRIDE; C9JKY3; -.
DR   Ensembl; ENST00000419334; ENSP00000389028; ENSG00000119888.
DR   UCSC; uc061iyf.1; human.
DR   EuPathDB; HostDB:ENSG00000119888.10; -.
DR   HGNC; HGNC:11529; EPCAM.
DR   OpenTargets; ENSG00000119888; -.
DR   eggNOG; ENOG410IFI6; Eukaryota.
DR   eggNOG; ENOG4111M3B; LUCA.
DR   GeneTree; ENSGT00390000018245; -.
DR   ChiTaRS; EPCAM; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000119888; Expressed in 196 organ(s), highest expression level in jejunal mucosa.
DR   ExpressionAtlas; C9JKY3; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.800.10; -; 1.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   SUPFAM; SSF57610; SSF57610; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JKY3,
KW   ECO:0000213|PeptideAtlas:C9JKY3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    199       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996568.
FT   DOMAIN      139    199       Thyroglobulin type-1.
FT                                {ECO:0000259|PROSITE:PS51162}.
FT   NON_TER     199    199       {ECO:0000313|Ensembl:ENSP00000389028}.
SQ   SEQUENCE   199 AA;  20954 MW;  9127873018D8A1DA CRC64;
     MAPPQVLAFG LLLAAATATF AAAQEGEARI GAELWSWAGL GGSGPRPSAP ETGIIGRGPR
     GRAFQRGDRT VRPCSGSGPP RGRKRRGPSR GAASLRSFAR LECVCENYKL AVNCFVNNNR
     QCQCTSVGAQ NTVICSKLAA KCLVMKAEMN GSKLGRRAKP EGALQNNDGL YDPDCDESGL
     FKAKQCNGTS MCWCVNTAG
//