ID C9JKV3_HUMAN Unreviewed; 215 AA. AC C9JKV3; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 16-JAN-2019, entry version 62. DE SubName: Full=Tissue factor pathway inhibitor {ECO:0000313|Ensembl:ENSP00000409177}; DE Flags: Fragment; GN Name=TFPI {ECO:0000313|Ensembl:ENSP00000409177}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409177, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000409177, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000409177} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007319; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC098485; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JKV3; -. DR SMR; C9JKV3; -. DR jPOST; C9JKV3; -. DR MaxQB; C9JKV3; -. DR PeptideAtlas; C9JKV3; -. DR PRIDE; C9JKV3; -. DR Ensembl; ENST00000435414; ENSP00000409177; ENSG00000003436. DR UCSC; uc061qmu.1; human. DR EuPathDB; HostDB:ENSG00000003436.14; -. DR HGNC; HGNC:11760; TFPI. DR OpenTargets; ENSG00000003436; -. DR GeneTree; ENSGT00940000160767; -. DR HOGENOM; HOG000231818; -. DR ChiTaRS; TFPI; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000003436; Expressed in 200 organ(s), highest expression level in placenta. DR ExpressionAtlas; C9JKV3; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro. DR CDD; cd00109; KU; 2. DR Gene3D; 4.10.410.10; -; 2. DR InterPro; IPR002223; Kunitz_BPTI. DR InterPro; IPR036880; Kunitz_BPTI_sf. DR InterPro; IPR020901; Prtase_inh_Kunz-CS. DR InterPro; IPR008296; TFPI-like. DR InterPro; IPR029864; TFPI1. DR PANTHER; PTHR10083:SF317; PTHR10083:SF317; 1. DR Pfam; PF00014; Kunitz_BPTI; 2. DR PIRSF; PIRSF001620; TFPI; 1. DR PRINTS; PR00759; BASICPTASE. DR SMART; SM00131; KU; 2. DR SUPFAM; SSF57362; SSF57362; 2. DR PROSITE; PS00280; BPTI_KUNITZ_1; 2. DR PROSITE; PS50279; BPTI_KUNITZ_2; 2. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:C9JKV3, KW ECO:0000213|MaxQB:C9JKV3, ECO:0000213|PeptideAtlas:C9JKV3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 215 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002996567. FT DOMAIN 54 104 BPTI/Kunitz inhibitor. FT {ECO:0000259|PROSITE:PS50279}. FT DOMAIN 112 162 BPTI/Kunitz inhibitor. FT {ECO:0000259|PROSITE:PS50279}. FT SITE 64 65 Reactive bond. FT {ECO:0000256|PIRSR:PIRSR001620-1}. FT SITE 122 123 Reactive bond. FT {ECO:0000256|PIRSR:PIRSR001620-1}. FT SITE 214 215 Reactive bond. FT {ECO:0000256|PIRSR:PIRSR001620-1}. FT NON_TER 215 215 {ECO:0000313|Ensembl:ENSP00000409177}. SQ SEQUENCE 215 AA; 24606 MW; D338BFC7B9FB1580 CRC64; MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTREKPD FCFLEEDPGI CRGYITRYFY NNQTKQCERF KYGGCLGNMN NFETLEECKN ICEDGPNGFQ VDNYGTQLNA VNNSLTPQST KVPSLFEFHG PSWCLTPADR GLCRA //