ID   C9JKR3_HUMAN            Unreviewed;      1057 AA.
AC   C9JKR3;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 76.
DE   SubName: Full=Semaphorin-5B {ECO:0000313|Ensembl:ENSP00000195173};
GN   Name=SEMA5B {ECO:0000313|Ensembl:ENSP00000195173};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000195173, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000195173, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000195173}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AC078794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001243277.1; NM_001256348.1.
DR   UniGene; Hs.210870; -.
DR   ProteinModelPortal; C9JKR3; -.
DR   PRIDE; C9JKR3; -.
DR   Ensembl; ENST00000195173; ENSP00000195173; ENSG00000082684.
DR   GeneID; 54437; -.
DR   UCSC; uc011bju.2; human.
DR   CTD; 54437; -.
DR   EuPathDB; HostDB:ENSG00000082684.14; -.
DR   HGNC; HGNC:10737; SEMA5B.
DR   OpenTargets; ENSG00000082684; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XQZC; LUCA.
DR   GeneTree; ENSGT00940000156712; -.
DR   HOGENOM; HOG000047106; -.
DR   OrthoDB; 64683at2759; -.
DR   ChiTaRS; SEMA5B; human.
DR   GenomeRNAi; 54437; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000082684; Expressed in 125 organ(s), highest expression level in cerebral cortex.
DR   ExpressionAtlas; C9JKR3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.20.100.10; -; 5.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 2.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF00090; TSP_1; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00209; TSP1; 4.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   SUPFAM; SSF82895; SSF82895; 4.
DR   PROSITE; PS51004; SEMA; 1.
DR   PROSITE; PS50092; TSP1; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00656526};
KW   Membrane {ECO:0000256|SAAS:SAAS00106123, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JKR3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1057       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996466.
FT   TRANSMEM    940    963       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    495       Sema. {ECO:0000259|PROSITE:PS51004}.
SQ   SEQUENCE   1057 AA;  116124 MW;  B0E53D8B29A188BB CRC64;
     MVLAGPLAVS LLLPSLTLLV SHLSSSQDVS SEPSSEQQLC ALSKHPTVAF EDLQPWVSNF
     TYPGARDFSQ LALDPSGNQL IVGARNYLFR LSLANVSLLQ ATEWASSEDT RRSCQSKGKT
     EEECQNYVRV LIVAGRKVFM CGTNAFSPMC TSRQVGNLSR TIEKINGVAR CPYDPRHNST
     AVISSQGELY AATVIDFSGR DPAIYRSLGS GPPLRTAQYN SKWLNEPNFV AAYDIGLFAY
     FFLRENAVEH DCGRTVYSRV ARVCKNDVGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE
     LQSAFHLPEQ DLIYGVFTTN VNSIAASAVC AFNLSAISQA FNGPFRYQEN PRAAWLPIAN
     PIPNFQCGTL PETGPNENLT ERSLQDAQRL FLMSEAVQPV TPEPCVTQDS VRFSHLVVDL
     VQAKDTLYHV LYIGTESGTI LKALSTASRS LHGCYLEELH VLPPGRREPL RSLRILHSAR
     ALFVGLRDGV LRVPLERCAA YRSQGACLGA RDPYCGWDGK QQRCSTLEDS SNMSLWTQNI
     TACPVRNVTR DGGFGPWSPW QPCEHLDGDN SGSCLCRARS CDSPRPRCGG LDCLGPAIHI
     ANCSRNGAWT PWSSWALCST SCGIGFQVRQ RSCSNPAPRH GGRICVGKSR EERFCNENTP
     CPVPIFWASW GSWSKCSSNC GGGMQSRRRA CENGNSCLGC GVEFKTCNPE GCPEVRRNTP
     WTPWLPVNVT QGGARQEQRF RFTCRAPLAD PHGLQFGRRR TETRTCPADG SGSCDTDALV
     EVLLRSGSTS PHTVSGGWAA WGPWSSCSRD CELGFRVRKR TCTNPEPRNG GLPCVGDAAE
     YQDCNPQACP GEDICLGLHT EEALCATQAC PEGWSPWSEW SKCTDDGAQS RSRHCEELLP
     GSSACAGNSS QSRPCPYSEI PVILPASSME EATDCAGFNL IHLVATGISC FLGSGLLTLA
     VYLSCQHCQR QSQESTLVHP ATPNHLHYKG GGTPKNEKYT PMEFKTLNKN NLIPDDRANF
     YPLQQTNVYT TTYYPSPLNK HSFRPEASPG QRCFPNS
//