ID C9JIZ6_HUMAN Unreviewed; 527 AA. AC C9JIZ6; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 16-JAN-2019, entry version 74. DE SubName: Full=Prosaposin {ECO:0000313|Ensembl:ENSP00000378392}; GN Name=PSAP {ECO:0000313|Ensembl:ENSP00000378392}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378392, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000378392, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000378392} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC073370; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731541; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JIZ6; -. DR SMR; C9JIZ6; -. DR jPOST; C9JIZ6; -. DR PeptideAtlas; C9JIZ6; -. DR PRIDE; C9JIZ6; -. DR Ensembl; ENST00000394934; ENSP00000378392; ENSG00000197746. DR UCSC; uc057twt.1; human. DR EuPathDB; HostDB:ENSG00000197746.13; -. DR HGNC; HGNC:9498; PSAP. DR OpenTargets; ENSG00000197746; -. DR eggNOG; KOG1340; Eukaryota. DR eggNOG; ENOG410XSI5; LUCA. DR GeneTree; ENSGT00940000156695; -. DR HOGENOM; HOG000049216; -. DR OMA; CKNYINQ; -. DR ChiTaRS; PSAP; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000197746; Expressed in 243 organ(s), highest expression level in visceral pleura. DR ExpressionAtlas; C9JIZ6; baseline and differential. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0005764; C:lysosome; IEA:InterPro. DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro. DR InterPro; IPR003119; SAP_A. DR InterPro; IPR007856; SapB_1. DR InterPro; IPR008138; SapB_2. DR InterPro; IPR008373; Saposin. DR InterPro; IPR011001; Saposin-like. DR InterPro; IPR021165; Saposin_chordata. DR InterPro; IPR008139; SaposinB_dom. DR Pfam; PF02199; SapA; 2. DR Pfam; PF05184; SapB_1; 4. DR Pfam; PF03489; SapB_2; 4. DR PIRSF; PIRSF002431; Saposin; 1. DR PRINTS; PR01797; SAPOSIN. DR SMART; SM00162; SAPA; 2. DR SMART; SM00741; SapB; 4. DR SUPFAM; SSF47862; SSF47862; 4. DR PROSITE; PS51110; SAP_A; 2. DR PROSITE; PS50015; SAP_B; 4. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002431-1}; KW Proteomics identification {ECO:0000213|EPD:C9JIZ6, KW ECO:0000213|MaxQB:C9JIZ6, ECO:0000213|PeptideAtlas:C9JIZ6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 527 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002997746. FT DOMAIN 18 58 Saposin A-type. FT {ECO:0000259|PROSITE:PS51110}. FT DOMAIN 59 142 Saposin B-type. FT {ECO:0000259|PROSITE:PS50015}. FT DOMAIN 194 278 Saposin B-type. FT {ECO:0000259|PROSITE:PS50015}. FT DOMAIN 314 395 Saposin B-type. FT {ECO:0000259|PROSITE:PS50015}. FT DOMAIN 408 489 Saposin B-type. FT {ECO:0000259|PROSITE:PS50015}. FT DOMAIN 491 527 Saposin A-type. FT {ECO:0000259|PROSITE:PS51110}. FT COILED 138 158 {ECO:0000256|SAM:Coils}. FT DISULFID 63 138 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 66 132 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 94 106 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 198 274 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 201 268 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 230 241 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 318 391 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 321 385 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 349 360 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 412 485 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 415 479 {ECO:0000256|PIRSR:PIRSR002431-1}. FT DISULFID 443 454 {ECO:0000256|PIRSR:PIRSR002431-1}. SQ SEQUENCE 527 AA; 58441 MW; D7FDB9DC50FA2F22 CRC64; MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI CKNYISQYSE IAIQMMMHMS LQQPKEICAL VGFCDEVKEM PMQTLVPAKV ASKNVIPALE LVEPIKKHEV PAKSDVYCEV CEFLVKEVTK LIDNNKTEKE ILDAFDKMCS KLPKSLSEEC QEVVDTYGSS ILSILLEEVS PELVCSMLHL CSGTRLPALT VHVTQPKDGG FCEVCKKLVG YLDRNLEKNS TKQEILAALE KGCSFLPDPY QKQCDQFVAE YEPVLIEILV EVMDPSFVCL KIGACPSAHK PLLGTEKCIW GPSYWCQNTE TAAQCNAVEH CKRHVWN //