ID   C9JIT1_HUMAN            Unreviewed;        87 AA.
AC   C9JIT1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-DEC-2018, entry version 59.
DE   SubName: Full=Metabotropic glutamate receptor 3 {ECO:0000313|Ensembl:ENSP00000390037};
DE   Flags: Fragment;
GN   Name=GRM3 {ECO:0000313|Ensembl:ENSP00000390037};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390037, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000390037, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000390037}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC002081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JIT1; -.
DR   SMR; C9JIT1; -.
DR   PeptideAtlas; C9JIT1; -.
DR   PRIDE; C9JIT1; -.
DR   Ensembl; ENST00000421579; ENSP00000390037; ENSG00000198822.
DR   UCSC; uc064eyc.1; human.
DR   EuPathDB; HostDB:ENSG00000198822.10; -.
DR   HGNC; HGNC:4595; GRM3.
DR   OpenTargets; ENSG00000198822; -.
DR   eggNOG; KOG1056; Eukaryota.
DR   eggNOG; ENOG410XR6W; LUCA.
DR   GeneTree; ENSGT00940000153406; -.
DR   ChiTaRS; GRM3; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000198822; Expressed in 98 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; C9JIT1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR001234; GPCR_3_mtglu_rcpt_3.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01053; MTABOTROPC3R.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00488977};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JIT1};
KW   Receptor {ECO:0000256|SAAS:SAAS00138718};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00488977};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488977}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25     87       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996558.
FT   NON_TER      87     87       {ECO:0000313|Ensembl:ENSP00000390037}.
SQ   SEQUENCE   87 AA;  9866 MW;  234B25E862F0026E CRC64;
     MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK GTGTEECGRI
     NEDRGIQRLE AMLFAIDEIN KDDYLLP
//