ID   C9JH98_HUMAN            Unreviewed;       101 AA.
AC   C9JH98;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 71.
DE   SubName: Full=Neuropilin-2 {ECO:0000313|Ensembl:ENSP00000404279};
DE   Flags: Fragment;
GN   Name=NRP2 {ECO:0000313|Ensembl:ENSP00000404279};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404279, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000404279, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000404279}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AC007362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; C9JH98; -.
DR   PeptideAtlas; C9JH98; -.
DR   PRIDE; C9JH98; -.
DR   Ensembl; ENST00000450507; ENSP00000404279; ENSG00000118257.
DR   UCSC; uc061rrp.1; human.
DR   EuPathDB; HostDB:ENSG00000118257.16; -.
DR   HGNC; HGNC:8005; NRP2.
DR   OpenTargets; ENSG00000118257; -.
DR   eggNOG; ENOG410IHB5; Eukaryota.
DR   eggNOG; ENOG410ZPIE; LUCA.
DR   GeneTree; ENSGT00940000155270; -.
DR   HOGENOM; HOG000039978; -.
DR   ChiTaRS; NRP2; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000118257; Expressed in 176 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; C9JH98; baseline and differential.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   CDD; cd00041; CUB; 1.
DR   Gene3D; 2.60.120.290; -; 1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR014648; Neuropilin.
DR   InterPro; IPR027143; Neuropilin-2.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR44185; PTHR44185; 1.
DR   PANTHER; PTHR44185:SF2; PTHR44185:SF2; 1.
DR   Pfam; PF00431; CUB; 1.
DR   SMART; SM00042; CUB; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
DR   PROSITE; PS01180; CUB; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS01008102};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JH98,
KW   ECO:0000213|PeptideAtlas:C9JH98};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    101       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008412916.
FT   DOMAIN       28    101       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DISULFID     28     55       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   NON_TER     101    101       {ECO:0000313|Ensembl:ENSP00000404279}.
SQ   SEQUENCE   101 AA;  11722 MW;  F838813683131E02 CRC64;
     MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY
     APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL L
//