ID   PRRT4_HUMAN             Reviewed;         899 AA.
AC   C9JH25; A4D0Z9; C9JVW7;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Proline-rich transmembrane protein 4;
DE   Flags: Precursor;
GN   Name=PRRT4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=C9JH25-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=C9JH25-2; Sequence=VSP_039273, VSP_039275;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=C9JH25-3; Sequence=VSP_039274;
CC         Note=No experimental confirmation available.;
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DR   EMBL; AC010655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236947; EAL24313.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83645.1; -; Genomic_DNA.
DR   EMBL; BC063892; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS47698.2; -. [C9JH25-2]
DR   CCDS; CCDS55160.1; -. [C9JH25-1]
DR   RefSeq; NP_001108198.2; NM_001114726.2. [C9JH25-2]
DR   RefSeq; NP_001167635.1; NM_001174164.1. [C9JH25-1]
DR   RefSeq; XP_005250399.1; XM_005250342.3. [C9JH25-1]
DR   RefSeq; XP_005250400.1; XM_005250343.3. [C9JH25-1]
DR   RefSeq; XP_006716048.1; XM_006715985.3. [C9JH25-1]
DR   RefSeq; XP_016867694.1; XM_017012205.1. [C9JH25-1]
DR   RefSeq; XP_016867695.1; XM_017012206.1. [C9JH25-2]
DR   UniGene; Hs.381096; -.
DR   ProteinModelPortal; C9JH25; -.
DR   BioGrid; 135071; 1.
DR   STRING; 9606.ENSP00000415026; -.
DR   iPTMnet; C9JH25; -.
DR   PhosphoSitePlus; C9JH25; -.
DR   BioMuta; PRRT4; -.
DR   jPOST; C9JH25; -.
DR   PaxDb; C9JH25; -.
DR   PRIDE; C9JH25; -.
DR   ProteomicsDB; 10169; -.
DR   ProteomicsDB; 10170; -. [C9JH25-2]
DR   ProteomicsDB; 10171; -. [C9JH25-3]
DR   Ensembl; ENST00000446477; ENSP00000415026; ENSG00000224940. [C9JH25-1]
DR   Ensembl; ENST00000489835; ENSP00000419296; ENSG00000224940. [C9JH25-2]
DR   Ensembl; ENST00000535159; ENSP00000445239; ENSG00000224940. [C9JH25-1]
DR   GeneID; 401399; -.
DR   KEGG; hsa:401399; -.
DR   UCSC; uc022akx.2; human. [C9JH25-1]
DR   CTD; 401399; -.
DR   EuPathDB; HostDB:ENSG00000224940.8; -.
DR   GeneCards; PRRT4; -.
DR   HGNC; HGNC:37280; PRRT4.
DR   HPA; HPA046373; -.
DR   HPA; HPA052681; -.
DR   neXtProt; NX_C9JH25; -.
DR   OpenTargets; ENSG00000224940; -.
DR   PharmGKB; PA165618245; -.
DR   eggNOG; ENOG410IVG1; Eukaryota.
DR   eggNOG; ENOG4112B6V; LUCA.
DR   GeneTree; ENSGT00730000111591; -.
DR   HOGENOM; HOG000252926; -.
DR   HOVERGEN; HBG101172; -.
DR   InParanoid; C9JH25; -.
DR   OMA; SRGLHAF; -.
DR   OrthoDB; 921831at2759; -.
DR   PhylomeDB; C9JH25; -.
DR   GenomeRNAi; 401399; -.
DR   PRO; PR:C9JH25; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000224940; Expressed in 81 organ(s), highest expression level in hypothalamus.
DR   ExpressionAtlas; C9JH25; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Membrane; Phosphoprotein;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    899       Proline-rich transmembrane protein 4.
FT                                /FTId=PRO_0000394498.
FT   TRANSMEM    370    390       Helical. {ECO:0000255}.
FT   TRANSMEM    392    412       Helical. {ECO:0000255}.
FT   TRANSMEM    430    450       Helical. {ECO:0000255}.
FT   TRANSMEM    467    487       Helical. {ECO:0000255}.
FT   TRANSMEM    500    520       Helical. {ECO:0000255}.
FT   COMPBIAS    373    516       Leu-rich.
FT   COMPBIAS    522    525       Poly-Arg.
FT   COMPBIAS    799    862       Ser-rich.
FT   MOD_RES     641    641       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:B2RU40}.
FT   VAR_SEQ     370    575       Missing (in isoform 3). {ECO:0000305}.
FT                                /FTId=VSP_039274.
FT   VAR_SEQ     370    429       VGALFGLVALLALLALALLPWRCPPGAPCLALLDLLLLSAG
FT                                TTRAFPLFYDAYGHRDRLP -> RLHRGLPPALPNQPATQH
FT                                RGGPLQRGPACAWPLPGPCLRGRSAWARTLPHRLAGDRGQG
FT                                Q (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_039273.
FT   VAR_SEQ     430    899       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_039275.
SQ   SEQUENCE   899 AA;  92712 MW;  4E03C2B27A57A772 CRC64;
     MARHGCLGLG LFCCVLFAAT VGPQPTPSIP GAPATTLTPV PQSEASMLSL NLGLNFKFHL
     RGPAAVWGSP VTETQPLSLG PGQEPGEEVA SGLRTDPLWE LLVGSSGNSL TEWGSTEGGS
     KPRASSLLPE STSRRSGPSD GPTAPYQPRR STVTWDTALM VTALPSSAPR PHQSELELKF
     DMALRAGAAP TLGHRTLPLL PSLRASLAEI AGRLGPFGFF GTTLSPLRNF SGLSPPGETT
     STSSASGVSG SLGFLGTTLS LPPYSLERKL SSPSPLDPAA SLSFASIATT SLDPTVPISG
     PDDLSPPASL GNPSGQPECG PGSCSVGELP EREGQPPEAP RPLFFLTLEA DWAEARARWG
     LAWEAHVYGV GALFGLVALL ALLALALLPW RCPPGAPCLA LLDLLLLSAG TTRAFPLFYD
     AYGHRDRLPA LAWLLLQDLP LPCLAAGLGL ACLLLARPRP PRCPTGLAAL LLLGLGLAAA
     AALGSAAHRP LRPLRLASRG LHAFLAAFLS GLLLALSCWG GRRRRAGAPL GGSGFKGATP
     LPQGRSPFAP RESWRRAART APVAGTFGLL SGALQGYEVL HALGYGGQSG LEGPWPWWAF
     QLGLRLGEVG VALPLALLGL YPALCSPRVP PRCWAKLFRL SPGHAAPLLP GGWVTGPPDK
     EPLGSAIARG DAELLQLCAL AGPGPDLLLQ GGGCRGFEGA AANPAPSPAS SPCSDYTVDF
     RPPSPINLRR SIEEALCSEA LLAPGLFQGP AFEDALPGLG LYRTASLGTG GRASERSGEA
     SGPAAPPELP SPGAWPAGSS VSSGSFCGLS RDSSSMLLCS SPDRPPRCPL VCVLSPPRPS
     GSSPSLPASG SYQALSPPSR DSPEPASELQ AEEALLQEQF LDACRQIDEL SVGSDTIDL
//