ID   C9JGI4_HUMAN            Unreviewed;       617 AA.
AC   C9JGI4;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
DE            EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE   AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN   Name=GALNT15 {ECO:0000313|Ensembl:ENSP00000395873};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395873, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000395873, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000395873}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU361242,
CC         ECO:0000256|SAAS:SAAS00405920};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|RuleBase:RU361242, ECO:0000256|SAAS:SAAS00405767}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane
CC       protein {ECO:0000256|RuleBase:RU361242}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC       subfamily. {ECO:0000256|RuleBase:RU361242,
CC       ECO:0000256|SAAS:SAAS00589955}.
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DR   EMBL; AC087858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001305980.1; NM_001319051.1.
DR   UniGene; Hs.411308; -.
DR   ProteinModelPortal; C9JGI4; -.
DR   PeptideAtlas; C9JGI4; -.
DR   PRIDE; C9JGI4; -.
DR   Ensembl; ENST00000437509; ENSP00000395873; ENSG00000131386.
DR   GeneID; 117248; -.
DR   UCSC; uc062hel.1; human.
DR   CTD; 117248; -.
DR   EuPathDB; HostDB:ENSG00000131386.17; -.
DR   HGNC; HGNC:21531; GALNT15.
DR   OpenTargets; ENSG00000131386; -.
DR   eggNOG; KOG3736; Eukaryota.
DR   eggNOG; ENOG410XPMK; LUCA.
DR   GeneTree; ENSGT00940000160808; -.
DR   HOGENOM; HOG000038227; -.
DR   OrthoDB; 606683at2759; -.
DR   UniPathway; UPA00378; -.
DR   ChiTaRS; GALNT15; human.
DR   GenomeRNAi; 117248; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000131386; Expressed in 179 organ(s), highest expression level in spinal cord.
DR   ExpressionAtlas; C9JGI4; baseline and differential.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00161; RICIN; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   Pfam; PF00652; Ricin_B_lectin; 1.
DR   SUPFAM; SSF50370; SSF50370; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|RuleBase:RU361242,
KW   ECO:0000256|SAAS:SAAS00484762};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU361242,
KW   ECO:0000256|SAAS:SAAS00130854};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU361242,
KW   ECO:0000256|SAAS:SAAS00485149};
KW   Lectin {ECO:0000256|RuleBase:RU361242, ECO:0000256|SAAS:SAAS00485025};
KW   Manganese {ECO:0000256|RuleBase:RU361242,
KW   ECO:0000256|SAAS:SAAS00130855};
KW   Membrane {ECO:0000256|SAAS:SAAS00130919};
KW   Proteomics identification {ECO:0000213|MaxQB:C9JGI4,
KW   ECO:0000213|PeptideAtlas:C9JGI4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU361242,
KW   ECO:0000256|SAAS:SAAS00130854};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00130919};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00130919}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    617       Polypeptide N-
FT                                acetylgalactosaminyltransferase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002996435.
FT   DOMAIN      515    592       Ricin B-type lectin.
FT                                {ECO:0000259|PROSITE:PS50231}.
SQ   SEQUENCE   617 AA;  70351 MW;  871531D5024E9FF8 CRC64;
     MLLRKRYRHR PCRLQFLLLL LMLGCVLMMV AMLHPPHHTL HQTVTAQASK HSPEARYRLD
     FGESQDWVLE AEDEGEEYSP LEGLPPFISL REDQLLVAVA LPQARRNQSQ GRRGGSYRLI
     KQPRRQDKEA PKRDWGADED GEVSEEEELT PFSLDPRGLQ EALSARIPLQ RALPEVRHPL
     CLQQHPQDSL PTASVILCFH DEAWSTLLRT VHSILDTVPR AFLKEIILVD DLSQQGQLKS
     ALSEYVARLE GVKLLRSNKR LGAIRARMLG ATRATGDVLV FMDAHCECHP GWLEPLLSRI
     AGDRSRVVSP VIDVIDWKTF QYYPSKDLQR GVLDWKLDFH WEPLPEHVRK ALQSPISPIR
     SPVVPGEVVA MDRHYFQNTG AYDSLMSLRG GENLELSFKA WLCGGSVEIL PCSRVGHIYQ
     NQDSHSPLDQ EATLRNRVRI AETWLGSFKE TFYKHSPEAF SLSKAEKPDC MERLQLQRRL
     GCRTFHWFLA NVYPELYPSE PRPSFSGKLH NTGLGLCADC QAEGDILGCP MVLAPCSDSR
     QQQYLQHTSR KEIHFGSPQH LCFAVRQEQV ILQNCTEEGL AIHQQHWDFQ EDENRANSAA
     AEAYQRPLTF QQIVNNG
//