ID   C9JFF1_HUMAN            Unreviewed;       994 AA.
AC   C9JFF1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 69.
DE   SubName: Full=Seizure protein 6 homolog {ECO:0000313|Ensembl:ENSP00000337407};
GN   Name=SEZ6 {ECO:0000313|Ensembl:ENSP00000337407};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000337407, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000337407, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000337407}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AC024267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JFF1; -.
DR   SMR; C9JFF1; -.
DR   PeptideAtlas; C9JFF1; -.
DR   PRIDE; C9JFF1; -.
DR   Ensembl; ENST00000335960; ENSP00000337407; ENSG00000063015.
DR   UCSC; uc060dhh.1; human.
DR   EuPathDB; HostDB:ENSG00000063015.19; -.
DR   HGNC; HGNC:15955; SEZ6.
DR   OpenTargets; ENSG00000063015; -.
DR   eggNOG; ENOG410IS3V; Eukaryota.
DR   eggNOG; ENOG410YA6K; LUCA.
DR   GeneTree; ENSGT00940000156995; -.
DR   HOGENOM; HOG000206919; -.
DR   ChiTaRS; SEZ6; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000063015; Expressed in 107 organ(s), highest expression level in cerebellar vermis.
DR   ExpressionAtlas; C9JFF1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 5.
DR   CDD; cd00041; CUB; 2.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00084; Sushi; 5.
DR   SMART; SM00032; CCP; 5.
DR   SMART; SM00042; CUB; 2.
DR   SUPFAM; SSF49854; SSF49854; 3.
DR   SUPFAM; SSF57535; SSF57535; 5.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS50923; SUSHI; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JFF1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    994       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005669216.
FT   TRANSMEM    926    948       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      355    414       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      416    527       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      530    591       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      593    704       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      708    767       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      769    832       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      836    897       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID    416    443       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID    738    765       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   994 AA;  107374 MW;  3863BCCBDDABCC22 CRC64;
     MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ PERGVHFVTT
     APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA PFTPSPLPRL ANQDSRPVFT
     SPTPAMAAVP TQPQSKEGPW SPESESPMLR ITAPLPPGPS MAVPTLGPGE IASTTPPSRA
     WTPTQEGPGD MGRPWVAEVV SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT
     PGPCSWNFSG PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV
     EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP
     RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA TQPFWDSKEP VCIGECPGVI
     RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE
     APPVYDSYEV EYLPIEGLLS SGKHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG
     NFSSSTPTYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS
     AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDIRVLRI GPGDVLTFYD GDDLTARVLG
     QYSGPRSHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW
     KSPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLTWSE DLPSCQRVTS CHDPGDVEHS
     RRLISSPKFP VGATVQYICD QGFVLMGSSI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG
     LSAPENGARS PEKQLHPAGA TIHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAASL
     DGSTTVAAWM VAKAPAASST LDAAHIAAAI FLPLVAMVLL VGGVYFYFSR LQGKSSLQLP
     RPRPRPYNRI TIESAFDNPT YETGSLSFAG DERI
//